Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer.
Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer.
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SMAD家族成员在非小细胞肺癌中的独特表达及其预后价值。
DOI：
10.1097/md.0000000000019451
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yanxia Jiang
中科院分区：
文献类型：
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作者：
Zhenguo Zeng;Yuting Yang;Cheng Qing;Zhiguo Hu;Yiming Huang;Chaoqi Zhou;Dan Li;Yanxia Jiang
非小细胞肺癌（NSCLC）是全球癌症死亡的主要原因。尽管多学科疗法已广泛用于非小细胞肺癌，但其总体预后仍然非常差，可能是由于缺乏有效的预后生物标志物。SMAD是一种重要的转录因子，在肿瘤发生中起着重要作用。SMAD在多种肿瘤中的异常表达，可作为某些恶性肿瘤的预后指标。然而，SMAD家族成员的表达和预后作用，特别是在mRNA水平上，在NSCLC中仍然是难以捉摸的。在本研究中，我们通过分析几个在线数据库，包括ONCOMINE、基因表达谱交互分析、人类蛋白质图谱数据库、Kaplan-Meier曲线、cBioPortal和注释、可视化和集成发现数据库，报告了单个SMAD在NSCLC患者中的不同表达和预后价值。SMAD 6/7/9在NSCLC中的mRNA水平显著下调，SMAD 2/3/4/5/6/7/9 mRNA水平的异常与NSCLC的预后相关。SMAD 2/3/4/5/6/7/9可作为NSCLC的预后生物标志物和潜在靶点，从而促进NSCLC患者的个性化治疗策略。
Non-small cell lung cancer (NSCLC) is the major cause of cancer mortality worldwide. Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis remains very poor, presumably owing to lack of effective prognostic biomarkers. SMAD, a well-known transcription factor, plays an essential role in carcinogenesis. Aberrant expression of SMAD have been found in various cancers, and may be regarded as prognostic indicator for some malignancies. However, the expression and prognostic role of SMAD family member, especially at the mRNA level, remain elusive in NSCLC. In the present study, we report the distinct expression and prognostic value of individual SMAD in patients with NSCLC by analyzing several online databases including ONCOMINE, Gene Expression Profiling Interactive Analysis, Human Protein Atlas database, Kaplan–Meier plotter, cBioPortal, and Database for Annotation, Visualization and Integrated Discovery. The mRNA levels of SMAD6/7/9 in NSCLC were significantly down-regulated in NSCLC, and aberrant SMAD2/3/4/5/6/7/9 mRNA levels were all correlated with the prognosis of NSCLC. Collectively, SMAD2/3/4/5/6/7/9 may server as prognostic biomarkers and potential targets for NSCLC, and thus facilitate the customized treatment strategies for NSCLC patients.