Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy
Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy
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DOI：
10.1007/s10147-012-0449-x
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发表时间：
2013-10-01
影响因子：
3.3
通讯作者：
Fujii, Masato
中科院分区：
文献类型：
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作者：
Kano, Satoshi;Homma, Akihiro;Fujii, Masato
本研究旨在评估挽救性手术在口咽癌（OPC）初次放化疗（CRT）失败病例中的作用。523例既往未经治疗的OPC患者的数据来自日本临床肿瘤学组（JCOG）头颈癌研究组的12个机构。在接受CRT的170例患者中，35例患者（21%）有局部复发或残留病变。仅11例患者接受了进一步的挽救手术，24例患者接受了非手术治疗。在患者年龄和同时出现的局部复发方面，两组之间存在统计学显著差异。手术治疗的5年生存率为49.1%，非手术治疗的5年生存率为16.3%，早期治疗应慎重选择，充分考虑手术治疗的局限性。
The current study aimed to assess the role of salvage surgery for failure cases of oropharyngeal cancer (OPC) undergoing initial chemoradiotherapy (CRT).The data for 523 patients with previously untreated OPC were gathered from 12 institutions belonging to the Head and Neck Cancer Study Group in Japan Clinical Oncology Group (JCOG).Of the 170 patients who received CRT, 35 patients (21 %) had local recurrence or residual disease. Only 11 patients underwent further salvage surgery, and 24 patients received nonsurgical treatment. There were statistically significant differences between the two groups in terms of patient age and the presence of a simultaneous regional recurrence. The 5-year overall survival rates for the patients who underwent salvage surgery were 49.1 %, whereas those for the patients who received nonsurgical treatment were 16.3 %.The initial treatment method for OPC should be decided carefully and the limitations of salvage surgery should be fully considered.