Finding neuroelectric activity under magnetic-field oscillations (NAMO) with magnetic resonance imaging in vivo
Finding neuroelectric activity under magnetic-field oscillations (NAMO) with magnetic resonance imaging in vivo
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DOI：
10.1073/pnas.0605486103
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发表时间：
2006-08-15
影响因子：
11.1
通讯作者：
Song, Allen W.
中科院分区：
文献类型：
--
作者：
Truong, Trong-Kha;Song, Allen W.
神经损伤技术是研究人类神经系统功能和改善神经系统疾病临床诊断的最重要工具之一。然而，大多数常用的技术受到其侵入性或无法在空间或时间上准确定位神经活动的限制。先前尝试使用MRI通过检测由神经元电流诱导的磁场变化来直接对体内神经电活动进行成像，这是具有挑战性的，因为信号变化非常小，并且存在诸如血液动力学调制等混杂因素。在这里，我们描述了一种MRI技术，该技术使用振荡磁场梯度来显着放大和检测神经电活动诱导的洛伦兹效应，并且我们证明了其在电刺激期间对人体正中神经体内感觉神经激活进行成像的有效性。手腕。这种直接、实时、无创的神经成像技术可能在神经科学中得到广泛的应用。
Neuroinraging techniques are among the most important tools for investigating the function of the human nervous system and for improving the clinical diagnosis of neurological disorders. However, most commonly used techniques are limited by their invasiveness or their inability to accurately localize neural activity in space or time. Previous attempts at using MRI to directly image neuroelectric activity in vivo through the detection of magnetic field changes induced by neuronal currents have been challenging because of the extremely small signal changes and confounding factors such as hemodynamic modulations. Here we describe an MRI technique that uses oscillating magnetic field gradients to significantly amplify and detect the Lorentz effect induced by neuroelectric activity, and we demonstrate its effectiveness in imaging sensory nerve activation in vivo in the human median nerve during electrical stimulation of the wrist. This direct, real-time, and noninvasive neuroimaging technique may potentially find broad applications in neurosciences.