Oral Helicobacter pylori, its relationship to successful eradication of gastric H. pylori and saliva culture confirmation.
Oral Helicobacter pylori, its relationship to successful eradication of gastric H. pylori and saliva culture confirmation.
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口腔幽门螺杆菌及其与成功根除胃幽门螺杆菌的关系及唾液培养证实。
DOI：
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发表时间：
2014
影响因子：
2.2
通讯作者：
G. Y. Zhang
中科院分区：
文献类型：
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作者：
X. M. Wang;K. Yee;N. Hazeki;J. Li;H. Fu;M. L. Huang;G. Y. Zhang
本研究旨在探讨口腔幽门螺杆菌（h.p ylori）的存在及其在口腔内与胃幽门螺杆菌感染根除成功率的关系，确定含赖氨酸（0.4%）和单月桂酸甘油（0.2%）的漱口水溶液是否能够消除口腔幽门螺杆菌，并利用唾液幽门螺杆菌培养证实口腔幽门螺杆菌的存在。共招募159例有症状的胃痛患者和118例无症状的胃痛患者，采用唾液幽门螺杆菌抗原试验（HPS）、幽门螺杆菌鞭毛蛋白试验（HPF）、尿素呼气试验（UBT C(13)）和聚合酶链反应（PCR）试验进行检测，并通过唾液培养进行证实。测试对象也接受了各种治疗。结果发现，UBT C（13）阴性患者口腔内存在幽门螺杆菌抗原。传统的胃根除治疗对口腔幽门螺杆菌感染的有效率仅为10.67%（10.67%）。在UBT C阴性的口腔幽门螺杆菌感染患者组（13）中，在95%可信区间（CI）内，漱口水溶液对口腔幽门螺杆菌感染的有效率为72.58%。传统药物除胃洁牙（TC）有效率不足10%。在95% CI范围内，口腔感染的治疗使胃感染的根除成功率从61.33%提高到82.26%。我们得出结论，胃幽门螺杆菌的根除成功率与口腔幽门螺杆菌感染有显著关系。
The present study was designed to explore the existence of oral Helicobacter pylori (H. pylori), its relationship in the oral cavity to the success rate of eradication of the gastric H. pylori infection, and to determine if the mouthwash solution contained lysine (0.4%) and glycerol monolaurate (0.2%) (LGM) could eliminate oral H. pylori, as well as using the saliva H. pylori culture to confirm the existence of oral H. pylori. A total of 159 symptomatic individuals with stomach pain and 118 asymptomatic individuals with no stomach complaints, were recruited and tested using the saliva H. pylori antigen test (HPS), the H. pylori flagellin test (HPF), the urea breath test (UBT C(13)) and the polymerase chain reaction (PCR) test, which tests were also confirmed by saliva culture. The test subjects also received various treatments. It was found that the H. pylori antigen exists in the oral cavity in UBT C(13) negative individuals. Traditional treatment for gastric eradication had only a 10.67 percent (10.67%) effectiveness rate on the oral H. pylori infection. In groups of patients with the oral H. pylori infection, but with negative UBT C(13), a mouthwash solution provided a 72.58% effectiveness rate in the 95% of the confidence interval (CI) ranges on the oral H. pylori infection. Traditional drug gastric eradication and teeth cleaning (TC) had less than a 10% effectiveness rate. Treatment of the oral infection increased the success rate of eradication of the stomach infection from 61.33% to 82.26% in the 95% CI ranges. We concluded that the successful rate of eradication of gastric H. pylori bears a significant relationship to the oral infection from H. pylori.