Cerebellar Neural Circuits Involving Executive Control Network Predict Response to Group Cognitive Behavior Therapy in Social Anxiety Disorder
Cerebellar Neural Circuits Involving Executive Control Network Predict Response to Group Cognitive Behavior Therapy in Social Anxiety Disorder
复制标题
涉及执行控制网络的小脑神经回路预测社交焦虑症群体认知行为疗法的反应
DOI：
10.1007/s12311-017-0845-x
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发表时间：
2017
期刊：
影响因子：
3.5
通讯作者：
Zhang Wei
中科院分区：
文献类型：
--
作者：
Yuan Minlan;Meng Yajing;Zhang Yan;Nie Xiaojing;Ren Zhengjia;Zhu Hongru;Li Yuchen;Lui Su;Gong Qiyong;Qiu Changjian;Zhang Wei
一些内在的连接网络，包括默认模式网络（DMN）和执行控制网络（ECN）可能是社交焦虑障碍（SAD）的基础。虽然小脑已被牵连在SAD的病理生理学和几个网络相关的高阶认知，它仍然是未知的DMN和ECN参与小脑区域是否表现出改变的静息状态功能连接（rsFC）与SAD的皮质网络。46例SAD患者和64例健康对照（HC）被纳入并提交基线静息状态功能磁共振成像（fMRI）。17例SAD患者完成治疗后临床评估后纳入小组认知行为治疗（CBT）。分别对两组小脑3个亚区的rsFC进行体素分析，并进行组间比较。进行全脑体素回归以检查小脑连接网络是否可以预测对CBT的反应。与基线时的HC相比，小脑亚区的rsFC回路较低（p< 0.05，经错误发现率校正）。左侧第一脚rsFC与背内侧前额叶皮质与症状严重程度呈负相关。SAD患者的临床评估在CBT后显著降低。较高的预处理小脑rsFC与角回和背外侧额叶皮质对应于CBT后更大的症状改善。涉及DMN和ECN的小脑rsFC回路可能是SAD的神经病理机制。涉及ECN的更强的预处理小脑rsFC电路表明预测CBT反应的潜在神经标志物。
Some intrinsic connectivity networks including the default mode network (DMN) and executive control network (ECN) may underlie social anxiety disorder (SAD). Although the cerebellum has been implicated in the pathophysiology of SAD and several networks relevant to higher-order cognition, it remains unknown whether cerebellar areas involved in DMN and ECN exhibit altered resting-state functional connectivity (rsFC) with cortical networks in SAD. Forty-six patients with SAD and 64 healthy controls (HC) were included and submitted to the baseline resting-state functional magnetic resonance imaging (fMRI). Seventeen SAD patients who completed post-treatment clinical assessments were included after group cognitive behavior therapy (CBT). RsFC of three cerebellar subregions in both groups was assessed respectively in a voxel-wise way, and these rsFC maps were compared by two-samplettests between groups. Whole-brain voxel-wise regression was performed to examine whether cerebellar connectivity networks can predict response to CBT. Lower rsFC circuits of cerebellar subregions compared with HC at baseline (p< 0.05, corrected by false discovery rate) were revealed. The left Crus I rsFC with dorsal medial prefrontal cortex was negatively correlated with symptom severity. The clinical assessments in SAD patients were significantly decreased after CBT. Higher pretreatment cerebellar rsFC with angular gyrus and dorsal lateral frontal cortex corresponded with greater symptom improvement following CBT. Cerebellar rsFC circuits involving DMN and ECN are possible neuropathologic mechanisms of SAD. Stronger pretreatment cerebellar rsFC circuits involving ECN suggest potential neural markers to predict CBT response.