Lesions of the rat basolateral amygdala reduce the behavioral response to ultrasonic vocalizations
Lesions of the rat basolateral amygdala reduce the behavioral response to ultrasonic vocalizations
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DOI：
10.1016/j.bbr.2019.112274
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发表时间：
2020-01
影响因子：
2.7
通讯作者：
Lisa-Maria Schönfeld;M. Zech;S. Schäble;M. Wöhr;T. Kalenscher
中科院分区：
文献类型：
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作者：
Lisa-Maria Schönfeld;M. Zech;S. Schäble;M. Wöhr;T. Kalenscher
大鼠发出超声波范围内的发声（超声波发声; USVs），其中50-kHz的USVs可以传达积极的情感状态，并诱导同种动物的接近行为，而22-kHz的USVs可能信号的负面情感状态和潜在的威胁。听50 kHz的USV可能是有益的，但目前还不清楚是哪些大脑机制负责将强化值分配给50 kHz的USV。通过收听22 kHz USV引起的行为反应是异质的，需要进一步表征。杏仁核是一个与社会感知、行为和奖励相关的区域。在这里，我们测试的假设，基底外侧杏仁核（BLA）在激励行为反应50 kHz和22 kHz USV的因果关系的作用。在放射状迷宫中，将BLA损伤或假损伤的大鼠反复暴露于50 kHz或22 kHz USV的回放。与假手术大鼠相比，在播放50 kHz或22 kHz USV期间，BL损伤大鼠在靠近USV扬声器的手臂上花费的时间更少。这种行为差异不是由于运动或一般听觉能力受损，表明BLA病变选择性地降低了对具有社会意义的刺激的反应性。这一发现进一步支持了BLA在激发社会交往者接近行为中起重要作用的假设。
Rats emit vocalizations in the ultrasonic range (ultrasonic vocalizations; USVs), of which 50-kHz USVs could communicate positive affective states and induce approach behavior in conspecifics, whereas 22-kHz USVs might signal negative affective states and potential threats. Listening to 50-kHz USVs can be rewarding, but it is unknown which brain mechanisms are responsible for the assignment of reinforcing value to 50-kHz USVs . The behavioral responses induced by listening to 22-kHz USVs are heterogeneous and need further characterization. The amygdala is a region relevant for social perception, behavior and reward. Here, we tested the hypothesis that the basolateral amygdala (BLA) plays a causal role in motivating behavioral responses to 50-kHz and 22-kHz USVs. Rats with lesions of the BLA or sham lesions were repeatedly exposed to playback of either 50-kHz or 22-kHz USVs in a radial maze. Compared to sham rats, BLA-lesioned rats spent less time in the arms close to the USV speaker during playback of both 50-kHz or 22-kHz USVs. This difference in behavior was not due to impaired motor or general auditory abilities, indicating that BLA lesions selectively reduced the responsiveness to stimuli with social significance. This finding provides further support for the hypothesis that the BLA plays an important role in motivating approach behavior to social reinforcers.