GENETIC-POLYMORPHISM AND EXON CHANGES OF THE CONSTANT REGIONS OF THE HUMAN T-CELL REARRANGING GENE-GAMMA
GENETIC-POLYMORPHISM AND EXON CHANGES OF THE CONSTANT REGIONS OF THE HUMAN T-CELL REARRANGING GENE-GAMMA
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DOI：
10.1073/pnas.83.24.9596
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发表时间：
1986-12-01
影响因子：
11.1
通讯作者：
RABBITTS, TH
中科院分区：
文献类型：
--
作者：
LEFRANC, MP;FORSTER, A;RABBITTS, TH
人T细胞重排基因γ的恒定区（C）基因的基因组核苷酸序列。给出了这些序列显示出相当大的等位基因和非等位基因变异。等位基因变体存在于C γ 1和C γ 2基因座的编码区（以及限制性内切酶位点）。都是C γ。基因的转录方向相同。此外，组织的非等位基因C. γ。基因揭示了一些有趣的特征：C γ 1基因，像小鼠的C γ。C γ 2基因具有三个外显子，而C γ 2基因具有四个外显子，包括复制的第二外显子，其将产生具有扩大的恒定区的推定蛋白质。然而，C γ 2中的这两个重复外显子已经失去了被认为参与链间二硫桥的半胱氨酸残基。
The genomic nucleotide sequences of the constant-region (C) genes of the human T-cell rearranging gene .gamma. are given. These sequences show considerable allelic and nonallelic variation. Allelic variants exist at both C.gamma.1 and C.gamma.2 loci in coding regions (as well as in restriction enzyme sites). Both C.gamma. genes are in the same transcriptional orientation. Moreover, the organization of the nonallelic C.gamma. genes reveals some interesting features: the C.gamma.1 gene, like the mouse C.gamma. gene, has three exons, whereas the C.gamma.2 gene had four exons, including a duplicated second exon that would create a putative protein with an enlarged constant region. However, these two duplicated exons in C.gamma.2 have lost the cysteine residue that is thought to be involved in the interchain disulfide bridge.