SUPPRESSION AND INDUCTION OF EPILEPTIC ACTIVITY BY NEURONAL GRAFTS
SUPPRESSION AND INDUCTION OF EPILEPTIC ACTIVITY BY NEURONAL GRAFTS
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DOI：
10.1073/pnas.85.23.9327
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发表时间：
1988-12-01
影响因子：
11.1
通讯作者：
GAGE, FH
中科院分区：
文献类型：
--
作者：
BUZSAKI, G;PONOMAREFF, G;GAGE, FH
将从蓝斑区或海马制备的胎鼠脑细胞悬液双侧植入成年大鼠的去皮质神经支配的倾向性海马。蓝斑核移植的动物对印防己毒素诱导的行为性癫痫发作有保护作用，发作间期尖峰明显减少。与此相反，在大鼠胚胎海马移植的发病率发作间期尖峰明显高于病变的控制，自发行为癫痫发作发生在几乎一半的动物。我们认为，神经元移植提供了一个替代的方法来研究癫痫脑活动的机制和控制。
Fetal rat brain cell suspensions prepared from either the locus coeruleus region or hippocampus were implanted bilaterally into the subcortically denervated seizure-prone hippocampus of adult rats. Animals with locus coeruleus grafts were protected against picrotoxin-induced behavioral seizures and had significantly fewer interictal spikes. In contrast, in rats with fetal hippocampal grafts the incidence of interictal spikes was significantly higher than in lesion-only controls, and spontaneous behavioral seizures occurred in almost half of the animals. We suggest that neuronal grafting offers an alternative method for studying the mechanisms and control of epileptic brain activity.