The effect of spatial structure on adaptation in Escherichia coli
The effect of spatial structure on adaptation in Escherichia coli
复制标题
空间结构对大肠杆菌适应的影响
作者：
L. Perfeito;M. Pereira;P. Campos;I. Gordo
生物种群通常在给定的空间结构中组织起来。然而，绝大多数群体遗传学研究都是基于每个个体在全球范围内竞争的群体。在这里，我们使用大肠杆菌的实验进化来直接测试最近做出的预测，即空间结构减缓适应，并且这种成本随着突变率的增加而增加。这是通过比较适应液体（非结构化）培养基的不同突变率的群体与在培养皿中在固体（结构化）培养基上进化的群体来研究的。我们发现，mutators适应更快的环境和适应是缓慢的，如果有空间结构。我们没有观察到显着差异的结构之间的增变基因和野生型人口，这表明克隆干扰是强烈的遗传背景。
Populations of organisms are generally organized in a given spatial structure. However, the vast majority of population genetic studies are based on populations in which every individual competes globally. Here we use experimental evolution in Escherichia coli to directly test a recently made prediction that spatial structure slows down adaptation and that this cost increases with the mutation rate. This was studied by comparing populations of different mutation rates adapting to a liquid (unstructured) medium with populations that evolved in a Petri dish on solid (structured) medium. We find that mutators adapt faster to both environments and that adaptation is slower if there is spatial structure. We observed no significant difference in the cost of structure between mutator and wild-type populations, which suggests that clonal interference is intense in both genetic backgrounds.
通过多个基因靶标的功能丧失和适应性丧失来衡量大肠杆菌突变株生长的后果。
影响因子：
3.3
作者：
Funchain,P;Yeung,A;Stewart,JL;Lin,R;Slupska,MM;Miller,JH
通讯作者：
Miller,JH