Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
复制标题
核酸副贫血结构：生物医学和生物纳米技术应用中功能纳米材料的有前景的构建模块
DOI：
10.1039/d2tb00605g
复制
发表时间：
2022
影响因子：
7
通讯作者：
Zhang, Fei
中科院分区：
文献类型：
--
作者：
Lee, Jung Yeon;Yang, Qi;Chang, Xu;Wisniewski, Henry;Olivera, Tiffany R.;Saji, Minu;Kim, Suchan;Perumal, Devanathan;Zhang, Fei
在过去的几十年里，DNA被认为是一种强大的自组装材料，能够以准埃的精度制作超分子纳米结构，这在材料科学，纳米工程和生物医学科学领域有着广泛的应用前景。值得注意的结构特征包括生物相容性、生物降解性、通过沃森-克里克碱基配对的高数字编码性、纳米尺度和表面可寻址性。复杂DNA纳米结构的自底向上制造依赖于基本DNA基序的设计，包括平行（PX）和反平行（AX）交叉。然而，与AX基序相比，paranemic或PX基序尚未被彻底探索用于构建基于DNA的纳米结构。在这篇综述中，我们总结了基于PX的DNA纳米结构的发展，突出的优点以及基于PX的组件的挑战，并给出了一个概述的结构和化学特征，使其在各种应用中的利用。这些作品涵盖了生物系统，动态系统和生物医学环境中基于PX的DNA纳米结构。对PX的结构和应用的未来可能的进展进行了总结，讨论和假设。
Over the past few decades, DNA has been recognized as a powerful self-assembling material capable of crafting supramolecular nanoarchitectures with quasi-angstrom precision, which promises various applications in the fields of materials science, nanoengineering, and biomedical science. Notable structural features include biocompatibility, biodegradability, high digital encodability by Watson–Crick base pairing, nanoscale dimension, and surface addressability. Bottom-up fabrication of complex DNA nanostructures relies on the design of fundamental DNA motifs, including parallel (PX) and antiparallel (AX) crossovers. However, paranemic or PX motifs have not been thoroughly explored for the construction of DNA-based nanostructures compared to AX motifs. In this review, we summarize the developments of PX-based DNA nanostructures, highlight the advantages as well as challenges of PX-based assemblies, and give an overview of the structural and chemical features that lend their utilization in a variety of applications. The works presented cover PX-based DNA nanostructures in biological systems, dynamic systems, and biomedical contexts. The possible future advances of PX structures and applications are also summarized, discussed, and postulated.