VHR/DUSP3 phosphatase: structure, function and regulation
VHR/DUSP3 phosphatase: structure, function and regulation
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DOI：
10.1111/febs.13263
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
Karolina Pavic;Guangyou Duan;M. Köhn
中科院分区：
文献类型：
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作者：
Karolina Pavic;Guangyou Duan;M. Köhn
牛痘H1相关（VHR）磷酸酶，也称为双特异性磷酸酶（DUSP）3，是磷酸酶DUSP（也称为DSP）家族的一个小成员。VHR偏好磷酸酪氨酸底物，并在细胞信号传导中发挥重要作用，包括细胞周期调节和DNA损伤反应，MAPK信号传导，血小板活化和血管生成。VHR/DUSP 3与几种人类癌症有关，其中已经描述了其肿瘤抑制和促进特性。我们给出了VHR/DUSP 3磷酸酶的详细概述，并将其与其最密切相关的磷酸酶DUSP 13 B，DUSP 26和DUSP 27进行了比较。
Vaccinia H1‐related (VHR) phosphatase, also known as dual‐specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases. VHR has a preference for phospho‐tyrosine substrates, and has important roles in cellular signaling ranging from cell‐cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR/DUSP3 has been implicated in several human cancers, where its tumor‐suppressing and ‐promoting properties have been described. We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.