Thyrotropin-releasing hormone (TRH) evokes chloride secretion via cholinergic pathways in the guinea-pig ileum.
Thyrotropin-releasing hormone (TRH) evokes chloride secretion via cholinergic pathways in the guinea-pig ileum.
复制标题
促甲状腺激素释放激素（TRH）通过豚鼠回肠中的胆碱能途径引起氯化物分泌。
DOI：
10.1016/0014-2999(89)90671-7
复制
发表时间：
1989
影响因子：
5
通讯作者：
Cooke,HJ
中科院分区：
文献类型：
--
作者：
Carey,HV;Cooke,HJ
在流量室中研究了促甲状腺激素释放激素（TRH）对豚鼠回肠离子转运的影响。TRH诱发的短路电流，这是由于活性阴离子分泌的浓度依赖性增加。对TRH的反应被河豚毒素阻止，几乎被阿托品消除，但不受美加明的影响。结果表明，TRH作为一种神经调质或神经递质，通过直接或间接激活胆碱能运动神经元来影响分泌过程。
The effect of thyrotropin-releasing hormone (TRH) on ion transport in the guinea-pig ileum was investigated in flux chambers. TRH evoked a concentration-dependent increase in short-circuit current that was due to active anion secretion. The response to TRH was prevented by tetrodotoxin and nearly abolished by atropine, but was not affected by mecamylamine. The results suggest that TRH plays a role as a neuromodulator or neurotransmitter that influences secretory processes by directly or indirectly activating cholinergic motor neurons.