Serious Infections Caused by Methicillin-Resistant Staphylococcus aureus
Serious Infections Caused by Methicillin-Resistant Staphylococcus aureus
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DOI：
10.1086/653519
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发表时间：
2010-09-15
影响因子：
11.8
通讯作者：
Razonable, Raymund R.
中科院分区：
文献类型：
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作者：
Boucher, Helen;Miller, Loren G.;Razonable, Raymund R.
尽管首次发现仅在> 40年前，但耐甲氧西林金黄色葡萄球菌（MRSA）已经经历了快速的进化变化和流行病学扩展，成为全球医院和社区获得性感染的主要原因。MRSA菌株对万古霉素耐药性的增加以及新抗生素（包括达托霉素和利奈唑胺）的可用性增加了治疗选择，但使临床治疗决策更具挑战性。本文描述了MRSA感染、菌血症和/或心内膜炎和骨髓炎的2种挑战性治疗表现的临床特征和管理问题。它还介绍了社区相关的MRSA感染和针对MRSA的预防策略的简要回顾。
Although first identified just >4 decades ago, methicillin-resistant Staphylococcus aureus (MRSA) has undergone rapid evolutionary changes and epidemiologic expansion to become a major cause of nosocomial and community-acquired infections worldwide. Increasing resistance to vancomycin among MRSA strains in conjunction with availability of new antibiotics, including daptomycin and linezolid, have increased treatment choices but made clinical treatment decisions more challenging. This article describes the clinical features and management issues of 2 challenging-to-treat manifestations of MRSA infection, bacteremia and/or endocarditis and osteomyelitis. It also presents a brief review of community-associated MRSA infections and preventive strategies directed against MRSA.