Etoposide Phosphate Enhances the Acetylation Level of Translation Elongation Factor 1A in PLC5 Cells
Etoposide Phosphate Enhances the Acetylation Level of Translation Elongation Factor 1A in PLC5 Cells
复制标题
磷酸依托泊苷增强 PLC5 细胞中翻译延伸因子 1A 的乙酰化水平
DOI：
10.1515/znc-2012-5-613
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Xue-fei Cai
中科院分区：
文献类型：
--
作者：
Jie-li Hu;Ge Xu;Ling Lei;Wenlu-Zhang;Yuan Hu;Ai-long Huang;Xue-fei Cai
Translation elongation factor 1A (eEF1A) is a factor critically involved in the process of protein synthesis. The activity of eEF1A has been shown by several studies to be regulated by post-translational modifi cations such as phosphorylation and dephosphorylation. However, until now less research has focused on other post-translational modifi cations of eEF1A, especially acetylation. In this report, we provide new evidence for the existence of eEF1A acetylation in PLC5 cells by immunoprecipitation and Western blotting. Using the histone deacetylase (HDAC) inhibitor trichostatin A (TSA), we found that the deacetylation of eEF1A is mainly attributable to classes I and II HDAC rather than class III HDAC, and, furthermore, that the antitumour agent etoposide phosphate (VP 16) enhances the acetylation of eEF1A in a synergistic way with TSA. Our data suggest the possibility that the increased acetylation of eEF1A could be a new mechanism for the antitumour effect of etoposide
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