Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer
Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer
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HOXC8 过度表达与上皮性卵巢癌的不良预后相关
DOI：
10.1177/1933719115625845
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发表时间：
2016-07-01
影响因子：
2.9
通讯作者：
Mao, Guoxin
中科院分区：
文献类型：
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作者：
Lu, Shumin;Liu, Rong;Mao, Guoxin
同源异型盒C8（HOXC 8）是一种转录因子，已被报道为几种肿瘤中的潜在驱动癌基因，并参与许多癌症相关蛋白的调节。在这项研究中，我们研究了HOXC 8在卵巢癌中的表达和作用。Western blot和免疫组化检测HOXC 8的表达。Kaplan-Meier曲线显示HOXC 8的高表达与卵巢上皮性癌（EOC）患者的不良预后有关。饥饿和再喂养实验检测细胞周期，提示HOXC 8在EOC细胞增殖中起关键作用。HOXC 8的小干扰RNA的耗竭抑制细胞增殖，迁移，并诱导EOC细胞凋亡。此外，HOXC 8敲低增加了ZAC 1的表达。由于HOXC 8的过度表达，我们的研究结果表明HOXC 8参与了EOC的进展，并可能成为EOC的潜在治疗方法。
Homeobox C8 (HOXC8) is a transcription factor that has been reported as a potential driver oncogene in several tumors and involved in the regulation of many cancer-related proteins. In this study, we investigated the expression and role of HOXC8 in ovarian cancer. Western blot and immunohistochemistry analyses were performed to detect the expression of HOXC8. Kaplan-Meier curve showed that high expression of HOXC8 was related to poor prognosis of patients with epithelial ovarian cancer (EOC). Starvation and refeeding assay were used to assess cell cycle, suggesting that HOXC8 played a critical role in EOC cell proliferation. HOXC8 depletion by small interfering RNA inhibited cell proliferation, migration, and induced apoptosis in EOC cells. Moreover, HOXC8 knockdown increased the expression of ZAC1. Owing to the overexpression of HOXC8, our findings implied that HOXC8 is involved in the progression of EOC and could be a potential therapeutical approach of EOC.