Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study.
Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study.
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DOI：
10.1016/j.ijcha.2015.07.006
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发表时间：
2015-12-07
期刊：
影响因子：
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通讯作者：
Northern Iwate Heart Disease Registry Consortium
中科院分区：
文献类型：
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作者：
Honma M;Tanaka F;Sato K;Onoda T;Sakai T;Nishiyama O;Matsumoto T;Onodera M;Sakata K;Nakamura M;Northern Iwate Heart Disease Registry Consortium
心衰（HF）住院发生率和流行率的性别特异性时间趋势，特别是与左心室射血分数（EF）降低和保留有关的情况，仍不清楚，特别是在亚洲普通人群中。我们在日本普通人群的老龄化队列中进行了一项为期10年的基于社区的心衰登记研究。调查期间共登记住院心衰2598例。在这1413例（55%）中，首次入院的是心衰（突发病例）。研究期分为5个2年期（T1, 2003-2004年；T2, 2005-2006年；T3, 2007-2008年；T4, 2009-2010年；T5, 2011-2012年），并对各期数据进行比较。经年龄调整的HF发病率（每105人年）在男性中保持稳定，但在女性中显著下降了25%（从T1时的104降至T5时的79；p表示趋势< 0.05）。在接受超声心动图检查的病例中（≈90%），男性HF合并保留EF的比例增加（从T1时的32%增加到T5时的43%；p表示趋势< 0.05），女性HF合并保留EF的比例相对较高，并在整个研究期间保持稳定（从T1时的52%增加到T5时的58%；p表示趋势；NS）。尽管在研究人群中，心衰的发病率在2003年至2012年间有所下降，尤其是女性，但保留肺泡的心衰比例随着时间的推移而增加。这些趋势表明，在亚洲老龄化人群中，保留EF的HF的未来流行率高于EF减少的HF。
Sex specific temporal trends in the incidence and prevalence of hospitalization for heart failure (HF), particularly in conjunction with reduced and preserved left ventricular ejection fraction (EF) remain unclear, especially in Asian general populations. We conducted a community based HF registration study over a 10 year period in an aging cohort of the Japanese general population. A total of 2598 cases of hospitalized HF were registered during the survey period. Of these 1413 cases (55%) were initial admissions for HF (incident case). The study period was divided into five 2-year terms (T1, 2003–2004; T2, 2005–2006; T3, 2007–2008; T4, 2009–2010; T5, 2011–2012), and data were compared among the terms. Age adjusted incidence of HF (per 105 person-year) remained stable in men, but decreased significantly by 25% in women (from 104 at T1 to 79 at T5; p for trend < 0.05). Among incident cases who underwent echocardiography (≈ 90%), the proportion of HF with preserved EF increased in men (from 32% at T1 to 43% at T5; p for trend < 0.05), and was relatively high and remained stable throughout the study period in women (from 52% at T1 to 58% at T5; p for trend; NS). Although the incidence of HF has declined especially in women between 2003 and 2012 in the study population, the proportion of HF with preserved EF has increased over time. These trends suggest a future prevalence of HF with preserved EF rather than HF with reduced EF in aging Asian populations.