LATENT CARCINOMA OF PROSTATE AT AUTOPSY IN 7 AREAS - COLLABORATIVE STUDY ORGANIZED BY INTERNATIONAL-AGENCY-FOR-RESEARCH-ON-CANCER, LYONS, FRANCE
LATENT CARCINOMA OF PROSTATE AT AUTOPSY IN 7 AREAS - COLLABORATIVE STUDY ORGANIZED BY INTERNATIONAL-AGENCY-FOR-RESEARCH-ON-CANCER, LYONS, FRANCE
复制标题
DOI：
10.1002/ijc.2910200506
复制
发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
TULINIUS, H
中科院分区：
文献类型：
--
作者：
BRESLOW, N;CHAN, CW;TULINIUS, H
在世界范围内对7个地区的潜伏性前列腺癌的频率和特征进行了比较研究，采用标准化方法和盲目显微镜评估，以减少选择和观察者的偏见。本文观察了1327例前列腺癌中发现的350例隐匿性癌的形态特征。与瑞典和西德的西欧人以及来自牙买加的黑人相比，来自香港和新加坡的两个中国人的潜在癌症发病率较低；以色列人和乌干达黑人的发病率介于两者之间。在调查的所有地区，微小潜伏性癌的发生率约为12%，且不随年龄变化。较大的潜伏性癌的发病率随着年龄的增长而急剧增加，并显示出类似于临床前列腺癌的区域到区域的变化。小癌几乎全部位于前列腺外半部，大小不一的潜伏性癌均匀分布于前列腺前后半部和前列腺外膜的左右两侧。当来自每个区域的切片由不同的病理学家独立评估时，诊断中的某些不一致被注意到。大多数分歧是通过重新阅读这些部分来解决的；它们的出现对地域比较没有重大影响。
A world-wide comparative study of the frequency and characteristics of latent carcinoma of the prostate was undertaken in 7 areas, using standardized methods and blind microscopic evaluation to reduce selection and observer bias. The morphological features of 350 latent carcinomas found in 1327 prostates were examined. Two Chinese populations, from Hong Kong and Singapore, showed a low frequency of latent carcinoma in comparison with western Europeans in Sweden and West Germany and negroes from Jamaica; an intermediate position was found for Israelis and black Ugandans. The frequency of small latent carcinomas was about 12% in all the areas investigated and did not vary with age. Rates for larger latent carcinomas increased sharply with age and showed an area-to-area variation resembling that of clinical carcinoma of prostate. The small carcinomas were almost exclusively situated in the outer half of the prostate and latent carcinomas of all sizes were evenly distributed between the anterior and posterior halves of the prostate and the right and left sides of the outer prostatic shell. Certain disagreements in diagnosis were noted when the sections from each area were evaluated independently by a different pathologist. Most disagreements were resolved by re-reading the sections; their occurrence had not significant effect on the geographical comparisons.