Neural membrane phospholipids in Alzheimer disease
Neural membrane phospholipids in Alzheimer disease
复制标题
DOI：
10.1007/bf00992508
复制
发表时间：
1995-11-01
影响因子：
4.4
通讯作者：
Horrocks, LA
中科院分区：
文献类型：
--
作者：
Wells, K;Farooqui, AA;Horrocks, LA
磷脂形成神经膜的骨架，提供流动性和渗透性。从尸检的阿尔茨海默病（AD）脑的不同区域制备两种质膜组分，一种来自突触体（SPM），另一种来自胶质细胞和神经元细胞体（PM）。从年龄匹配的对照脑制备相应的级分。AD脑的所有组分均显示出比对照脑显著更低水平的乙醇胺甘油磷脂和显著更高水平的丝氨酸甘油磷脂。在这些膜中没有观察到磷脂酰胆碱水平的差异。这些结果表明，质膜磷脂成分的改变可能参与了AD异常的信号转导和神经退行性变。
Phospholipids form the backbone of neural membranes, providing fluidity and permeability. Two plasma membrane fractions, one from synaptosomes (SPM), the other from glial and neuronal cell bodies (PM), were prepared from different regions of autopsied Alzheimer disease (AD) brains. Corresponding fractions were prepared from age-matched control brains. All fractions from AD brains showed significantly lower levels of ethanolamine glycerophospholipids and significantly higher levels of serine glycerophospholipids than the control brain. No differences were observed in phosphatidylcholine levels among these membranes. These results suggest that altered phospholipid composition of plasma membranes may be involved in the abnormal signal transduction and neurodegeneration in AD.