Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model
Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model
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DOI：
10.1016/s0014-2999(99)00931-0
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发表时间：
2000-03-10
影响因子：
5
通讯作者：
Omoto, S
中科院分区：
文献类型：
--
作者：
Kuzuhara, H;Nishiyama, S;Omoto, S
本研究旨在探讨大豆皂苷元A对刀豆蛋白A诱导的小鼠肝炎免疫反应所致肝损伤的影响。在刀豆球蛋白A处理后2小时，大豆皂苷A可显著减少肝脏炎性细胞的数量，显著降低血浆肿瘤坏死因子-α升高的水平，并在24小时显著降低血浆丙氨酸氨基转移酶的活性，减少肝实质细胞中的凋亡小体数，而对肝窦细胞中的凋亡小体数无明显影响。与大豆皂苷A对血浆丙氨酸转氨酶升高的预防作用相比，大豆皂苷A对升高的血浆肿瘤坏死因子-α水平的影响不明显。这些结果表明，大豆皂苷A直接抑制血浆肿瘤坏死因子-α的升高，进而抑制肝细胞的凋亡。从而在刀豆球蛋白A诱导的肝炎模型中预防肝损伤。(C)2000 Elsevier Science B.V.保留所有权利。
The present study was carried out to analyze the effects of soyasapogenol A on the liver injury mediated by the immune response in concanavalin A-induced hepatitis in mice. Soyasapogenol A reduced the number of infiltrating inflammatory cells in the liver and significantly lowered the elevated level of plasma tumor necrosis factor-alpha (TNF-alpha) 2 h after concanavalin A treatment, and then markedly reduced the elevated plasma alanine aminotransferase activity and decreased the number of apoptotic bodies in the Liver parenchymal cells but not in the sinusoidal cells at 24 h. Since the effect of soyasapogenol A on the elevated plasma TNF-alpha level was not appreciable compared to the preventive effect of soyasapogenol A on the elevated plasma alanine aminotransferase level, these results suggest that soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-ol, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model. (C) 2000 Elsevier Science B.V. All rights reserved.