Effects of lorazepam on prosaccades and saccadic adaptation
Effects of lorazepam on prosaccades and saccadic adaptation
复制标题
DOI：
10.1177/0269881120972424
复制
发表时间：
2021-01-01
影响因子：
4.1
通讯作者：
Ettinger, Ulrich
中科院分区：
文献类型：
--
作者：
Bey, Katharina;Lippold, Julia, V;Ettinger, Ulrich
背景：苯二氮卓类药物对跳跃性眼球运动有可靠的不良影响，但性别作为这些影响的潜在调节剂的影响尚不清楚。最近的一项研究报道，对女性扫视的空间一致性有更强的不利影响，这可能反映了小脑机制的性别差异。目的：我们的目的是进一步研究性别作为苯二氮卓类药物效应的潜在调节剂的作用，通过采用跳眼适应范式，这是已知的小脑功能敏感。方法：采用双盲、受试者内设计，共n=50名健康成人在0.5 mg劳拉西泮、1 mg劳拉西泮和安慰剂的作用下进行水平阶跃前游任务和跳跃性适应任务。结果：在前突任务中，劳拉西泮对峰值速度、潜伏期和空间一致性测量有不利影响。给药0.5 mg劳拉西泮会显著降低小鼠的增减适应能力，而给药1 mg则不会损害小鼠的适应学习能力。增重适应一般不太明显，不受药物影响。在两项任务中都没有明显的药物与性别的相互作用。结论：我们的结论是，低剂量的劳拉西泮损害了非性别的增减适应。然而，在高剂量时，疲劳的增加可能促进适应，从而抵消在低剂量时观察到的不利影响。关于前驱活动，我们的研究结果证实了峰值速度、潜伏期和空间测量是gaba能效应的敏感生物标志物。
Background:Benzodiazepines have reliable adverse effects on saccadic eye movements, but the impact of sex as a potential modulator of these effects is less clear. A recent study reported stronger adverse effects on the spatial consistency of saccades in females, which may reflect sex differences in cerebellar mechanisms.Aims:We aimed to further examine the role of sex as a potential modulator of benzodiazepine effects by employing the saccadic adaptation paradigm, which is known to be sensitive to cerebellar functioning.Methods:A total of n=50 healthy adults performed a horizontal step prosaccade task and a saccadic adaptation task under 0.5 mg lorazepam, 1 mg lorazepam and placebo in a double-blind, within-subjects design.Results:In the prosaccade task, lorazepam had adverse effects on measures of peak velocity, latency and spatial consistency. The administration of 0.5 mg lorazepam led to significant reductions in gain-decrease adaptation, while a dose of 1 mg did not impair adaptation learning. Gain-increase adaptation was generally less pronounced, and unaffected by the drug. There were no significant drugxsex interactions in either task.Conclusions:We conclude that a low dose of lorazepam impairs gain-decrease adaptation independent of sex. At higher doses, however, increasing fatigue may facilitate adaptation and thus counteract the adverse effects observed at lower doses. With regards to prosaccades, our findings confirm peak velocity as well as latency and spatial measures as sensitive biomarkers of GABAergic effects.