SOLUBILITY PROPERTIES IN POLYMERS AND BIOLOGICAL MEDIA .2. THE CORRELATION AND PREDICTION OF THE SOLUBILITIES OF NONELECTROLYTES IN BIOLOGICAL TISSUES AND FLUIDS
SOLUBILITY PROPERTIES IN POLYMERS AND BIOLOGICAL MEDIA .2. THE CORRELATION AND PREDICTION OF THE SOLUBILITIES OF NONELECTROLYTES IN BIOLOGICAL TISSUES AND FLUIDS
复制标题
DOI：
10.1021/jm00145a004
复制
发表时间：
1985-01-01
影响因子：
7.3
通讯作者：
WEATHERSBY, PK
中科院分区：
文献类型：
--
作者：
ABRAHAM, MH;KAMLET, MJ;WEATHERSBY, PK
生物系统中一系列非电解质溶质的溶解度，如血液、血浆、脑、肺、肝、肾、肌肉组织和人体脂肪，通过一个形式为log Ltissue = c + w log Lwater + olog Loil的方程进行关联和预测，其中L为奥斯特瓦尔德溶解度系数（或气/液分配系数）。常数o和w的比值给出了给定生物组织或液体的油性的度量。对于许多类型的非电解质溶质，很有可能对其在水和油中的溶解度（气/液分配系数）进行简单的测量，从而准确预测其在上述生物溶剂中的溶解度以及组织/血液分配系数。稀有气体和无机气体H2、N2、CO和O2的溶解度可以通过更简单的方程log Ltissue = l “ RG + d ”来关联，其中l “和d ”是表征相的常数，RG是一个已知参数，通过对一系列溶剂体系的溶解度进行标准化和平均得到，表征溶质。上述两个方程都可以预测生物溶剂中L的值，误差在0.0.75左右。20%，与实验测量的精度相当。[永久性气体和蒸气在生物液体和组织中的溶解度是麻醉学、毒理学、肺生理学和高压氧生理学中一个至关重要的课题。在目前的一系列研究中，它也可以作为药理活性高沸点液体和固体非电解质在这些系统中的溶解度研究的介绍。
Solubilities of a range of nonelectrolyte solutes in biological systems, such s blood, plasma, brain, lung, liver, kidney, muscle tissue and human fat, are correlated and predicted through an equation that takes the form log Ltissue = c + w log Lwater + o log Loil, where L is the Ostwald solubility coefficient (or gas/liquid partition coefficient). The ratio of the constants o and w gives a measure of the oilness of a given biological tissue or fluid. The strong possibility exists that, for many types of nonelectrolyte solutes, simple measurements of solubilities in water and oil (gas/liquid partition coefficients) will allow accurate predictions of solubilities in the above biological solvents, as well as tissue/blood partition coefficients. The solubility of rare gases and the inorganic gases H2, N2, CO and O2 may be correlated through the simpler equation log Ltissue = l''RG + d'', where l'' and d'' are constants that characterize the phase, and RG is a known parameter, obtained by normalizing and averaging solubilities over a range of solvent systems, that characterizes the solute. Both of the above equations allow prediction of L in biological solvents to within .apprx. 20%, which compares well with the precison of the experimental measurements. [The solubility of permanent gases and vapors in biological fluids and tissues is a topic of fundamental importance in anethesiology, toxicology, pulmonary and hyperbaric physiology. In the present series of investigations, it also serves as an introduction to the study of solubility of pharmacologically active higher boiling liquid and solid nonelctrolytes in such systems.].