Human habit neural circuitry may be perturbed in eating disorders.
Human habit neural circuitry may be perturbed in eating disorders.
复制标题
人类习惯的神经回路可能会因饮食失调而受到干扰。
DOI：
10.1126/scitranslmed.abo4919
复制
发表时间：
2023
影响因子：
17.1
通讯作者：
Halpern,CaseyH
中科院分区：
文献类型：
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作者：
Wang,AllanR;Kuijper,FieneMarie;Barbosa,DanielAN;Hagan,KelseyE;Lee,Eric;Tong,Elizabeth;Choi,EunYoung;McNab,JenniferA;Bohon,Cara;Halpern,CaseyH
调节习惯性行为发展和执行的基于回路的机制涉及复杂的皮质-纹状体相互作用，已经在动物模型中进行了研究，最近在人类中也进行了研究。然而，与习惯形成有关的人脑回路如何在精神障碍中受到干扰仍不清楚。首先，我们从人类Connectome Project的数据中使用概率轨迹图确定了感觉运动壳核和联合尾状核在人脑中的位置。我们发现，在患有暴饮暴食障碍和神经性暴食症的人类中，感觉运动壳核的多变量连接性发生了改变，改变的程度与进食行为紊乱的严重程度有关。此外，这种回路异常的程度与感觉运动壳核的平均弥散率和纹状体中基础多巴胺D2/3受体结合电位的降低有关，这与先前报道的动物模型中微结构的变化和多巴胺信号介导习惯学习的情况一致。我们的发现表明，人类的习惯学习和暴饮暴食行为之间存在神经回路，这可能在一定程度上解释了饮食失调和其他精神疾病常见的治疗抵抗行为。
Circuit-based mechanisms mediating the development and execution of habitual behaviors involve complex cortical-striatal interactions that have been investigated in animal models and more recently in humans. However, how human brain circuits implicated in habit formation may be perturbed in psychiatric disorders remains unclear. First, we identified the locations of the sensorimotor putamen and associative caudate in the human brain using probabilistic tractography from Human Connectome Project data. We found that multivariate connectivity of the sensorimotor putamen was altered in humans with binge eating disorder and bulimia nervosa and that the degree of alteration correlated with severity of disordered eating behavior. Furthermore, the extent of this circuit aberration correlated with mean diffusivity in the sensorimotor putamen and decreased basal dopamine D2/3receptor binding potential in the striatum, consistent with previously reported microstructural changes and dopamine signaling mediating habit learning in animal models. Our findings suggest a neural circuit that links habit learning and binge eating behavior in humans, which could, in part, explain the treatment-resistant behavior common to eating disorders and other psychiatric conditions.