Dynamic Determinants of Left Ventricular Filling: An Overview
Dynamic Determinants of Left Ventricular Filling: An Overview
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左心室充盈的动态决定因素：概述
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Frater
中科院分区：
文献类型：
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作者：
E. Yellin;E. Sonnenblick;R. Frater
左心室通过舒张时顺应性的动态变化（通过改变其壁应力）、非平衡形状的弹性反冲和舒张期被动接受血液而充满。加速血液和克服耗散能量损失所需的驱动力是由左心房的压力提供的，左心房作为被动顺从的储存库（其势能由右心室收缩提供），以及心房收缩时主动产生的力。心室充盈的效率及其决定随后的脑卒中容量的能力，部分取决于瓣膜在充盈期间大范围打开和保持打开的能力，在收缩期适当关闭的能力，以及保持关闭无泄漏的能力。
The left ventricle fills through dynamic changes in its compliance as it relaxes (by altering its wall stress), through elastic recoil from a nonequilibrium shape, and through passive acceptance of blood during diastole. The driving force necessary to accelerate the blood and to overcome dissipative energy losses is provided by the pressure in the left atrium which acts as a passively compliant reservoir (whose potential energy is provided by the right ventricular contraction), and by the active generation of force during atrial systole. The efficiency of ventricular filling, and its ability to determine the subsequent stroke volume, is in part determined by the ability of the valve to open widely and to stay open during filling, to close competently at systole, and to remain closed without leakage.