Second malignant neoplasms following radiotherapy.

Second malignant neoplasms following radiotherapy.
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放疗后第二次恶性肿瘤。

DOI:
10.3390/ijerph9124744
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发表时间:
2012-12-18
影响因子:
--
通讯作者:
Kumar S
Kumar S
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kumar S

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超过一半的癌症患者接受放射治疗作为治疗的一部分。随着长期癌症幸存者数量的增加,人们越来越担心辐射诱发的第二恶性肿瘤[SMN]的风险。对于儿童癌症幸存者来说,这种风险似乎最高。辐射诱发恶性肿瘤的确切机制和剂量反应关系尚不清楚,然而,人们越来越努力制定预防和减轻辐射诱发癌症的策略。本文重点介绍放疗后各器官 SMN 的发病率、病因和危险因素。
More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy.
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