The primary visual cortex in the mouse: Receptive field properties and functional organization
The primary visual cortex in the mouse: Receptive field properties and functional organization
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DOI：
10.1007/bf00247312
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发表时间：
2004
影响因子：
2
通讯作者：
C. Métin;P. Godement;M. Imbert
中科院分区：
文献类型：
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作者：
C. Métin;P. Godement;M. Imbert
用单单位记录法研究了小鼠（C57 B16品系）初级视皮层细胞的感受野（RF）特性。我们已经研究了沿着径向和切线方向的皮质17区的功能组织。87%的视觉神经元可以根据它们对定向刺激和运动刺激的反应进行分类。细胞，首选一个闪烁或移动的酒吧的特定方向和其他方向的酒吧或斑点的反应不太好，被归类为方向选择性（简单RF 23%，复杂RF 18%）。此外，其中大多数是单向的（24%）。所有方向的代表性大致相同。定向RF的细胞主要记录在皮质层II-III的上部，在那里它们似乎是根据它们的首选方向聚集。对所有方向的点和条反应同样好的神经元（46%）被归类为“非定向”;在这些神经元中有几个子类。对点和条反应同样好，但优选刺激沿特定轴的沿着一个或两个方向移动的细胞被分类为非定向不对称细胞（单向14%，双向4%）。它们主要记录在颗粒上和颗粒下层。细胞不受刺激的形状和方向，同样很好地响应所有方向的运动被归类为对称单位。他们的感受野分为ON（11%），OFF（1%），ON/ OFF（11%），或对静止刺激无反应（5%）。这些细胞主要发现于第IV层，其中它们构成了记录细胞的大部分。RF的功能类型和大小之间没有明显的相关性。然而，最大比例的小RF被发现在第IV层。在小鼠纹状皮质的双眼段中，对侧眼的影响占主导地位。这一段中95%的细胞被驱动通过对侧眼。然而，70%的细胞被双眼激活，表明相当大的双眼整合发生在这个皮质段。眼优势变化少沿着径向比沿着切线方向的皮质。
Receptive field (RF) characteristics of cells in primary visual cortex of the mouse (C57B16 strain) were studied by single unit recording. We have studied the functional organization of area 17 along both the radial and tangential dimensions of the cortex. Eighty seven percent of the visual neurons could be classified according to their responses to oriented stimuli and to moving stimuli. Cells which preferred a flashed or moving bar of a particular orientation and responded less well to bars of other orientations or to spots, were classified as orientation selective (simple RF 23%, complex RF 18%). The majority of them were, moreover, unidirectional (24%). All orientations were roughly equally represented. Cells with oriented RFs were recorded mostly in the upper part of cortical layers II–III, where they appeared to be clustered according to their preferred orientation. Neurons that responded equally well to spots and bars of all orientations (46%) were classified as “non-oriented”; among these neurons there were several subcategories. Cells which responded equally well to spots and bars but preferred stimuli moving along one or both directions of a particular axis were classified as non oriented asymmetric cells (unidirectional 14%, bidirectional 4%). They were recorded mainly in supra- and infra-granular layers. Cells unaffected by stimulus shape and orientation which responded equally well to all directions of movement were classified as symmetric units. They had receptive field classified as ON (11%), OFF (1%), ON/ OFF (11%), or were unresponsive to stationary stimuli (5%). These cells were mostly found in layer IV, in which they constituted the majority of recorded cells. There was no apparent correlation between the functional type and size of RFs. However, the greatest proportion of small RFs was found in layer IV. In the binocular segment of the mouse striate cortex, the influence of the contralateral eye predominated. Ninety five percent of cells in this segment were driven through the contralateral eye. However, 70% of cells were binocularly activated, showing that considerable binocular integration occured in this cortical segment. Ocular dominance varied less along the radial than along the tangential dimension of the cortex.