One node among many: sevoflurane-induced hypnosis and the challenge of an integrative network-level view of anaesthetic action.
One node among many: sevoflurane-induced hypnosis and the challenge of an integrative network-level view of anaesthetic action.
复制标题
许多节点中的一个：七氟烷诱导的催眠和麻醉作用的综合网络级视图的挑战。
DOI：
10.1016/j.bja.2023.11.002
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发表时间：
2024
影响因子：
9.8
通讯作者：
Kelz,MaxB
中科院分区：
文献类型：
--
作者：
McKinstry-Wu,AndrewR;Kelz,MaxB
基于他们已知的影响睡眠和唤醒的能力，Li和他的同事们证明了调节谷氨酸能桥脑脚被盖神经元的活动也改变了七氟醚诱导的催眠。这一发现增加了对共享睡眠-麻醉回路假说的支持。然而，对许多能够调节麻醉催眠的神经元簇的认识不断扩大，提出了一个问题，即不同的和解剖上相距遥远的位置最终如何相互作用，以协调大脑状态的全球变化。了解这些单独的部位是如何协同工作来扰乱认知和行为的，是麻醉机制研究的下一个挑战。
Building on their known ability to influence sleep and arousal, Li and colleagues show that modulating the activity of glutamatergic pedunculopontine tegmental neurones also alters sevoflurane-induced hypnosis. This finding adds support for the shared sleep-anaesthesia circuit hypothesis. However, the expanding recognition of many neuronal clusters capable of modulating anaesthetic hypnosis raises the question of how disparate and anatomically distant sites ultimately interact to coordinate global changes in the state of the brain. Understanding how these individual sites work in concert to disrupt cognition and behaviour is the next challenge for anaesthetic mechanisms research.