Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.
Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.
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DOI：
10.1016/j.cellsig.2020.109765
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发表时间：
2020-11
影响因子：
4.8
通讯作者：
Rada B
中科院分区：
文献类型：
--
作者：
Almutairi F;Lee JK;Rada B
G蛋白信号转导调节子10（Regulator of G protein signaling 10，RGS 10）属于RGS蛋白超家族，其通过存在保守的RGS结构域来定义，所述结构域典型地结合并灭活异源三聚体G蛋白。RGS蛋白作为GTP酶激活蛋白（GAP），其加速G蛋白α亚基上的GTP水解并导致G蛋白偶联受体下游的信号通路终止。RGS 10是D/R12亚家族中最小的蛋白质，选择性地与Gαi蛋白相互作用。它在许多细胞和组织中广泛表达，在脑和免疫细胞中表达最高。RGS 10表达通过表观遗传机制进行转录调控。虽然RGS 10缺乏在其他RGS蛋白中发现的多个定义的调节结构域，但RGS 10含有调节其表达、定位和功能的翻译后修饰位点。此外，RGS 10是调节多细胞生理过程的关键蛋白质，其中其表达的失调涉及各种疾病，包括帕金森病、多发性硬化症、骨硬化症、化学抗性卵巢癌和心脏肥大。本文综述了RGS 10的特性及其调控机制，并讨论了RGS 10在细胞生理学和多种疾病发病机制中的已知功能。
Regulator of G protein signaling 10 (RGS10) belongs to the superfamily of RGS proteins, defined by the presence of a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. RGS proteins act as GTPase activating proteins (GAPs), which accelerate GTP hydrolysis on the G-protein α subunits and result in termination of signaling pathways downstream of G protein-coupled receptors. RGS10 is the smallest protein of the D/R12 subfamily and selectively interacts with Gαi proteins. It is widely expressed in many cells and tissues, with the highest expression found in the brain and immune cells. RGS10 expression is transcriptionally regulated via epigenetic mechanisms. Although RGS10 lacks multiple of the defined regulatory domains found in other RGS proteins, RGS10 contains post-translational modification sites regulating its expression, localization, and function. Additionally, RGS10 is a critical protein in the regulation of physiological processes in multiple cells, where dysregulation of its expression has been implicated in various diseases including Parkinson’s disease, multiple sclerosis, osteopetrosis, chemoresistant ovarian cancer and cardiac hypertrophy. This review summarizes RGS10 features and its regulatory mechanisms, and discusses the known functions of RGS10 in cellular physiology and pathogenesis of several diseases.
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影响因子：
4.8
作者：
Alqinyah M;Hooks SB
通讯作者：
Hooks SB
DOI：
10.1016/s0167-4781(01)00342-6
发表时间：
2001-12-03
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
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影响因子：
3.6
作者：
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通讯作者：
Hooks, Shelley B.
影响因子：
4.8
作者：
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