Transparent nanocrystalline yttria-stabilized-zirconia calvarium prosthesis
Transparent nanocrystalline yttria-stabilized-zirconia calvarium prosthesis
复制标题
DOI：
10.1016/j.nano.2013.08.002
复制
发表时间：
2013-11-01
影响因子：
5.4
通讯作者：
Aguilar, Guillermo
中科院分区：
文献类型：
--
作者：
Damestani, Yasaman;Reynolds, Carissa L.;Aguilar, Guillermo
基于激光的诊断和治疗显示出对许多神经系统疾病的希望。然而，颅骨（颅骨）的透明度差限制了空间分辨率和交互深度，从而限制了这方面的机会。在这里，我们报告的初步结果，努力寻求解决这一限制，通过使用新的透明的颅植入物由纳米晶氧化钇稳定氧化锆（nc-YSZ）。使用光学相干断层扫描（OCT）在急性小鼠模型的底层大脑成像，我们表明，通过nc-YSZ植入物相对于原生颅骨成像时，信号强度得到改善。因此，这提供了支持nc-YSZ作为透明颅骨植入材料的可行性的初步证据。此外，它代表了实现我们正在开发的创新概念的关键第一步，该概念旨在最终提供一种临床可行的方法，用于光学访问大脑，按需，大面积，并在长期复发的基础上，而不需要重复开颅手术。来自临床编辑：在这项研究中，透明纳米晶氧化钇稳定氧化锆被用作实验性“颅骨假体”材料，使得能够用允许使用光学成像方法（诸如OCT）在循环的基础上光学进入大脑的材料来替换颅骨的节段。All rights reserved.
Laser-based diagnostics and therapeutics show promise for many neurological disorders. However, the poor transparency of cranial bone (calvaria) limits the spatial resolution and interaction depth that can be achieved, thus constraining opportunity in this regard. Herein, we report preliminary results from efforts seeking to address this limitation through use of novel transparent cranial implants made from nanocrystalline yttria-stabilized zirconia (nc-YSZ). Using optical coherence tomography (OCT) imaging of underlying brain in an acute murine model, we show that signal strength is improved when imaging through nc-YSZ implants relative to native cranium. As such, this provides initial evidence supporting the feasibility of nc-YSZ as a transparent cranial implant material. Furthermore, it represents a crucial first step towards realization of an innovative new concept we are developing, which seeks to eventually provide a clinically-viable means for optically accessing the brain, on-demand, over large areas, and on a chronically-recurring basis, without need for repeated craniectomies.From the Clinical Editor: In this study, transparent nanocrystalline yttria-stabilized-zirconia is used as an experimental "cranium prosthesis" material, enabling the replacement of segments of cranial bone with a material that allows for optical access to the brain on a recurrent basis using optical imaging methods such as OCT. (C) 2013 Elsevier Inc. All rights reserved.