Development of a composite orthopaedic pain scale in horses
Development of a composite orthopaedic pain scale in horses
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DOI：
10.1016/j.rvsc.2007.10.011
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Troncy, E.
中科院分区：
文献类型：
--
作者：
Bussieres, G.;Jacques, C.;Troncy, E.
本研究致力于在急性骨科疼痛实验马模型中开发和验证复合多因素疼痛量表 (CPS)。十八匹马被分配到对照组（有/无硬膜外镇痛镇静 - 吗啡、罗哌卡因、去托咪定和氯胺酮的混合物）和实验组：跗脚关节注射两性霉素 B 引起疼痛，镇痛方式为静脉注射或静脉注射。诱导滑膜炎后给予保泰松，或先发制人的硬膜外混合物，或先发制人的组合 2。观察者之间和观察者内部的重现性良好（0.8 < K < 1）。关键的具体和敏感的行为指标是对疼痛区域触诊、姿势的反应，以及价值较小的爪子在地板上、踢腹部和头部运动的反应。特别令人感兴趣的是 CPS 与无创血压 (P < 0.0001) 和血液皮质醇 (P < 0.002) 之间观察到的统计相关性。这项研究确立了一些行为和生理标准在确定马骨科疼痛强度方面的价值，并清楚地证明了先发制人的多模式镇痛比其他两种测试方案提供了更好的管理。 (C) 2007 Elsevier Ltd. 保留所有权利。
This study addresses development and validation of a composite multifactorial pain scale (CPS) in an experimental equine model of acute orthopaedic pain. Eighteen horses were allocated to control (sedation with/without epidural analgesia - mixture of morphine, ropivacaine, detomidine and ketamine) and experimental groups: amphotericin-B injection in the tarsocrural joint induced pain and analgesia was either i.v. phenylbutazone administered post-induction of synovitis, or pre-emptive epidural mixture, or a pre-emptive combination of the 2. Inter- and intra-observer reproducibility was good (0.8 < K < 1). The key specific and sensitive behavioural indices were response to palpation of the painful area, posture, and, of lesser value, pawing on the floor, kicking at abdomen and head movement. Of particular interest was the statistical correlation observed between the CPS and both non-invasive blood pressure (P < 0.0001) and blood cortisol (P < 0.002). This study established the value of some behavioural and physiological criteria in determining equine orthopaedic pain intensity and clearly demonstrated that pre-emptive, multimodal analgesia provided better management than the two other protocols tested. (C) 2007 Elsevier Ltd. All rights reserved.