Intermittent hypoxemia and oxidative stress in preterm infants
Intermittent hypoxemia and oxidative stress in preterm infants
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DOI：
10.1016/j.resp.2019.05.006
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发表时间：
2019-08-01
影响因子：
2.3
通讯作者：
Vento, Maximo
中科院分区：
文献类型：
--
作者：
Di Fiore, Juliann M.;Vento, Maximo
间歇性低氧血症事件（IH）在极早产儿中很常见，并与许多不良结局相关，包括视网膜病变或早产、喘息、支气管肺发育不良、认知或语言延迟和运动障碍。最近在动物和啮齿动物模型中的数据表明，IH的特定模式可能会增加发病风险。这些高风险的IH模式启动病理级联反应的途径尚不清楚，但动物模型表明氧化应激可能起作用。本文综述了早产儿出生后早期IH的模式，其与发病率的关系，新生儿相关的氧化应激生物标志物和IH与活性氧之间的关系。
Intermittent hypoxemia events (IH) are common in extremely preterm infants and are associated with many poor outcomes including retinopathy or prematurity, wheezing, bronchopulmonary dysplasia, cognitive or language delays and motor impairment. More recent data in animal and rodent models have suggested that specific patterns of IH may increase the risk for morbidity. The pathway by which these high risk patterns of IH initiate a pathological cascade is unknown but animal models suggest that oxidative stress may play a role. This review describes early postnatal patterns of IH in preterm infants, their relationship with morbidity, oxidative stress biomarkers relevant to the newborn infant and the relationship between IH and reactive oxygen species.