Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study.
Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study.
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DOI：
10.1111/acps.12959
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发表时间：
2019-01
影响因子：
6.7
通讯作者：
Kasper S
中科院分区：
文献类型：
--
作者：
Kautzky A;Dold M;Bartova L;Spies M;Kranz GS;Souery D;Montgomery S;Mendlewicz J;Zohar J;Fabbri C;Serretti A;Lanzenberger R;Dikeos D;Rujescu D;Kasper S
在“难治性抑郁症 (TRD)-III”样本中研究了临床变量，以复制欧洲研究联盟“难治性抑郁症研究组”(GSRD) 的早期发现，并能够跨样本预测 TRD 的治疗结果。 TRD 的定义是，在至少两次抗抑郁试验后，蒙哥马利和阿斯伯格抑郁评定量表 (MADRS) 评分≥22。缓解的定义是 MADRS 评分下降 ≥50% 且低于阈值 22。Logistic 回归用于在 916 名患者的 16 个临床变量中复制 TRD 预测因子。应用弹性网络回归来预测治疗结果。症状严重程度（比值比 (OR) = 3.31）、精神病症状（OR = 2.52）、自杀风险（OR = 1.74）、广泛性焦虑障碍（OR = 1.68）、住院状态（OR = 1.65）、先前服用抗抑郁药物的数量较多（OR = 1.23）、终生抑郁发作（OR = 1.15）以及当前发作的持续时间较长（OR = 1.022）会增加 TRD 的风险。在独立验证集 TRD-I 中，TRD 的预测准确度达到 0.86。症状严重程度、自杀风险、一生中抑郁发作次数较多以及合并焦虑症被视为 TRD 最突出的危险因素。 TRD-III 中的重要预测因素可以对 TRD-I 中的治疗结果进行稳健预测。
Clinical variables were investigated in the ‘treatment resistant depression (TRD)‐ III’ sample to replicate earlier findings by the European research consortium ‘Group for the Study of Resistant Depression’ (GSRD) and enable cross‐sample prediction of treatment outcome in TRD. TRD was defined by a Montgomery and Åsberg Depression Rating Scale (MADRS) score ≥22 after at least two antidepressive trials. Response was defined by a decline in MADRS score by ≥50% and below a threshold of 22. Logistic regression was applied to replicate predictors for TRD among 16 clinical variables in 916 patients. Elastic net regression was applied for prediction of treatment outcome. Symptom severity (odds ratio (OR) = 3.31), psychotic symptoms (OR = 2.52), suicidal risk (OR = 1.74), generalized anxiety disorder (OR = 1.68), inpatient status (OR = 1.65), higher number of antidepressants administered previously (OR = 1.23), and lifetime depressive episodes (OR = 1.15) as well as longer duration of the current episode (OR = 1.022) increased the risk of TRD. Prediction of TRD reached an accuracy of 0.86 in the independent validation set, TRD‐I. Symptom severity, suicidal risk, higher number of lifetime depressive episodes, and comorbid anxiety disorder were replicated as the most prominent risk factors for TRD. Significant predictors in TRD‐III enabled robust prediction of treatment outcome in TRD‐I.
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DOI：
10.1007/s00406-014-0529-1
发表时间：
2015-02-01
影响因子：
4.7
作者：
Degner, Detlef;Haust, Merle;Reulbach, Udo
通讯作者：
Reulbach, Udo
影响因子：
1.9
作者：
Papakostas, GI;Petersen, T;Nierenberg, AA
通讯作者：
Nierenberg, AA
影响因子：
64.3
作者：
Chekroud, Adam Mourad;Zotti, Ryan Joseph;Corlett, Philip Robert
通讯作者：
Corlett, Philip Robert
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
3.6
作者：
Fried, Eiko I.;van Borkulo, Claudia D.;Borsboom, Denny
通讯作者：
Borsboom, Denny