An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?
An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?
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DOI：
10.18632/oncotarget.180
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Green MR
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文献类型：
--
作者：
Sheng Z;Evans SK;Green MR
在癌细胞中高度表达并对其生存能力至关重要的基因是开发新型癌症治疗方法的有吸引力的靶点。激活转录因子5 （ATF5）是一种抗凋亡蛋白，在恶性胶质瘤中高表达，而在正常脑组织中不表达，对胶质瘤细胞的存活至关重要。最近的研究揭示了恶性胶质瘤中ATF5介导的重要生存途径；药物抑制该途径可导致小鼠肿瘤消退。ATF5在其他多种癌症中也有高表达，初步研究表明，ATF5介导的存活途径在多种人类癌细胞系中都有活性。因此，靶向这一途径可能对治疗多种癌症具有治疗意义。从这个角度来看，我们总结了ATF5的最新研究进展，重点关注其在促进癌症中的作用及其作为癌症治疗靶点的潜力。
Genes that are highly expressed in cancer cells and are essential for their viability are attractive targets for the development of novel cancer therapeutics. Activating transcription factor 5 (ATF5) is an anti-apoptotic protein that is highly expressed in malignant glioma but not normal brain tissues, and is essential for glioma cell survival. Recent work has revealed an essential survival pathway mediated by ATF5 in malignant glioma; pharmacological inhibition of this pathway leads to tumor regression in mice. ATF5 is also highly expressed in a variety of other cancers, and preliminary studies have shown that the ATF5-mediated survival pathway is active in diverse human cancer cell lines. Targeting this pathway may therefore have therapeutic implications for the treatment of a wide range of cancers. In this perspective, we summarize recent advances in ATF5 research, focusing on its role in promoting cancer and its potential as a target for cancer therapy.