Synthesis of 1, 5-Disubstituted Imidazoles Including an Imidazole Analogue of Prostaglandin from 4(5)-Hydroxymethylimidazole
Synthesis of 1, 5-Disubstituted Imidazoles Including an Imidazole Analogue of Prostaglandin from 4(5)-Hydroxymethylimidazole
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从 4(5)-羟甲基咪唑合成 1, 5-二取代咪唑，包括前列腺素的咪唑类似物
DOI：
10.1248/cpb.37.1481
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发表时间：
1989
影响因子：
1.7
通讯作者：
C. Eguchi
中科院分区：
文献类型：
--
作者：
Y. Amino;H. Eto;C. Eguchi
以4（5）-羟甲基咪唑盐酸盐为原料合成了前列腺素的咪唑类似物1-（6-羧己基）-5-[（E）-3-羟基-1-辛烯基]咪唑。关键步骤是4（5）-叔丁基二甲基硅氧基甲基咪唑的区域选择性烷基化，主要得到1，5-二取代咪唑。
1-(6-Carboxyhexyl)-5-[(E)-3-hydroxy-1-octenyl]midazole, an imidazole analogue of prostaglandin, was synthesized from 4(5)-hydroxymethylimidazole hydrochloride. The key step involves regioselective alkylation of 4(5)-tertbutyldimethylsilyloxymethylimidazole to give predominantly 1, 5-disubstituted imidazole.