Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus
Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus
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DOI：
10.1542/peds.104.1.55
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发表时间：
1999-07-01
期刊：
影响因子：
8
通讯作者：
Pass, RF
中科院分区：
文献类型：
--
作者：
Boppana, SB;Fowler, KB;Pass, RF
目标。确定患有复发性母体巨细胞病毒 (CMV) 感染的妇女的后代中症状性先天性巨细胞病毒 (CMV) 感染的频率，并描述人口统计学和新生儿发现的特征。方法。研究对象包括 1991 年至 1997 年间阿拉巴马大学医院新生儿病毒学筛查项目发现的有症状的先天性 CMV 感染婴儿，并参加了一项长期随访研究。通过分析怀孕前和分娩时收集的档案血清样本对母体感染进行分类。出生时的人口统计数据和临床结果是从孕产妇和新生儿医院记录以及初次评估时的父母那里收集的。结果。在研究期间发现的 47 名有先天性 CMV 感染症状的婴儿中，有 8 名婴儿的母亲已确诊为非原发性或复发性 CMV 感染。在研究期间，阿拉巴马大学医院出生的有先天性 CMV 感染症状的儿童中，只有大约 43% (20/47) 能够确定母体感染的类型。反复感染组和妊娠期间原发巨细胞病毒感染或未分类母亲感染的母亲所生婴儿的人口统计学特征没有显着差异。同样，两组儿童新生儿期临床异常的严重程度也没有差异。而且长期随访两组儿童后遗症发生率无显着差异。结论。有症状的先天性 CMV 感染可能发生在非原发性或复发性母体感染后。然而，在已有免疫力的女性所生的孩子中，有症状的先天性 CMV 感染的确切发病率仍有待确定。
Objectives. To determine the frequency of symptomatic congenital cytomegalovirus (CMV) infection in the offspring of women with a recurrent maternal CMV infection and to characterize the demographic and newborn findings.Methods. Study subjects consisted of infants with symptomatic congenital CMV infection identified by a newborn virologic screening program at the University of Alabama Hospital between 1991 and 1997 and were enrolled in a long-term follow-up study. Maternal infections were categorized by an analysis of archival serum specimens collected before pregnancy and at the time of delivery. Demographic data and clinical findings at birth were collected from maternal and newborn hospital records and from parents at the time of initial evaluation.Results. Of the 47 infants with symptomatic congenital CMV infection identified during the study period, 8 were born to mothers with a confirmed nonprimary or recurrent CMV infection. The type of maternal infection could be ascertained in only similar to 43% (20/47) of the children with symptomatic congenital CMV infection born at the University of Alabama Hospital during the study period. There were no significant differences in demographic characteristics of the recurrent infection group and the infants who were born to mothers with either primary CMV infection during pregnancy or unclassified maternal infection. Similarly, the range of severity of clinical abnormalities during the newborn period did not differ in the two groups of children. Furthermore, there were no significant differences in the incidence of sequelae at long-term follow-up in the two groups of children.Conclusions. Symptomatic congenital CMV infection can occur after a nonprimary or recurrent maternal infection. However, the exact incidence of symptomatic congenital CMV infection among children born to women with preexisting immunity remains to be defined.