Multivariate analysis of HLA-disease associations.
Multivariate analysis of HLA-disease associations.
复制标题
HLA-疾病关联的多变量分析。
作者：
P. Smouse;R. Williams
一个多变量的程序提出了HLA-疾病协会的分析。这个公式明确地解释了HLA复合体本身的内部相关性，既包括基因座内的相关性（由多项等位基因频率之和必须为1的事实引起），也包括基因座之间的相关性（由独立分类失败引起）。分析产生了一个单一的测试标准的关联的HLA复合体，作为一个整体，与疾病的问题：这个标准有一个近似卡方分布。整个测试可以方便地划分成各种有趣的和独立的子测试，所以问题的分解是可能的。该分析用来自威廉姆斯等人（1976，British Journal of Dermatology 95，163-167）的点滴状银屑病研究的数据来说明。相关问题的扩展被指出。
A multivariate procedure is presented for the analysis of HLA-disease associations. This formulation explicitly accounts for the inner correlations of the HLA complex itself, both within loci (arising from the fact that multinomial allelic frequencies must sum to unity) and between loci (arising from a failure of independent assortment). The analysis yields a single test criterion for association of the HLA complex, as a whole, with the disease in question: this criterion has an approximately chi square distribution. The overall test may conveniently be partitioned into a variety of interesting and independent subtests, so a decomposition of the problem is possible. The analysis is illustrated with data derived from a study of guttate psoriasis by Williams et al. (1976, British Journal of Dermatology 95, 163-167). Extensions to related problems are indicated.