Early skin immunological disturbance after Plasmodium-infected mosquito bites
Early skin immunological disturbance after Plasmodium-infected mosquito bites
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DOI：
10.1016/j.cellimm.2012.06.003
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发表时间：
2012-05-01
影响因子：
4.3
通讯作者：
Tadokoro, Carlos E.
中科院分区：
文献类型：
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作者：
da Silva, Henrique Borges;Caetano, Susana S.;Tadokoro, Carlos E.
虽然调节性T细胞（TCRs）在疟疾感染过程中的作用已被广泛研究，但这些研究仅集中在Treg在感染血液阶段的作用上;对TCRs和子孢子沉积在蚊子叮咬的真皮中的详细机制知之甚少。在本文中，我们表明，子孢子引入皮肤蚊虫叮咬增加的皮肤T细胞和树突状细胞（DC）的流动性。我们还显示了MHC II类和/或C 086在皮肤驻留树突状细胞亚型和巨噬细胞上表达的差异。从所观察到的进入引流淋巴结的APC数量的减少、常规CD 4 T细胞中的CD 28表达的抑制以及在裸鼠中发现的皮肤迁移的CD 4 T的低稳态增殖，表明TdR在疟原虫接种到哺乳动物宿主的初始阶段期间可能发挥重要作用。(C)2012 Elsevier Inc. All rights reserved.
Although the role of regulatory T cells (Tregs) during malaria infection has been studied extensively, such studies have focused exclusively on the role of Treg during the blood stage of infection; little is known about the detailed mechanisms of Tregs and sporozoite deposition in the dermis by mosquito bites. In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobility of skin Tregs and dendritic cells (DCs). We also show differences in MHC class II and/or C086 expression on skin-resident dendritic cell subtypes and macrophages. From the observed decrease of the number of APCs into draining lymph nodes, suppression of CD28 expression in conventional CD4 T cells, and a low homeostatic proliferation of skin-migrated CD4 T found in nude mice indicate that Tregs may play a fundamental role during the initial phase of malaria parasite inoculation into the mammalian host. (C) 2012 Elsevier Inc. All rights reserved.