Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: a population-based cohort study
Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: a population-based cohort study
复制标题
妊娠期间母体血清 HDL-c 浓度与新生儿出生体重之间的关联：一项基于人群的队列研究
DOI：
10.1186/s12944-020-01264-0
复制
发表时间：
2020-05-14
影响因子：
4.5
通讯作者：
Yu, Huanling
中科院分区：
文献类型：
--
作者：
Wang, Hongliang;Dang, Qinyu;Yu, Huanling
背景为了评估整个妊娠期间母体血清高密度脂蛋白胆固醇（HDL-c）浓度与新生儿出生体重（BW）和小于胎龄儿（SGA）births.MethodsA前瞻性队列的2241名孕妇从招募到分娩在2014年1月至2017年12月期间在中国北京的三家医院进行了随访。在妊娠第6-12、16、24和36周测量母体空腹血清脂质浓度。主要结局为新生儿BW。通过线性回归和线性混合效应模型估计母体HDL-c和BW之间的关联。优势比（OR）和95%的可信区间的SGA出生在HDL-C进行了评估，通过Logistic回归analysis.ResultsThere是一种趋势，即母亲在整个妊娠期HDL-C浓度较高的婴儿出生体重较低。妊娠24周和36周时，母体HDL-c浓度与体重呈负相关（B = − 34.044，P = 0.034; B = − 53.528，P = 0.000）。HDL-c的变化趋势与BW呈负相关（B = − 442.736，P = 0.000）。胎龄36周时，SGA新生儿母亲血清HDL-c水平明显高于对照组（P< 0.01）。HDL-c浓度为1.84-2.23 mmol/L、2.24-2.59 mmol/L和≥ 2.60 mmol/L的3组大鼠在36周时SGA发生率均高于HDL-c浓度最低组（< 1.83 mmol/L）（P<0.01，P <0.01，P < 0.001）。妊娠36周时母体HDL-c水平升高（HDL-c：1.84-2.23 mmol/L、2.24-2.59 mmol/L和≥ 2.60 mmol/L）与SGA发生率呈正相关（OR = 1.900，P = 0.008; OR = 1.893，P = 0.008; OR = 1.975，P = 0.004）。HDL-c的变化趋势与SGA的发生呈正相关（OR = 9.772，P = 0.000）。妊娠第36周HDL-c浓度升高可增加SGA的风险。母体HDL-C在整个妊娠期的变化趋势与较小的新生儿尺寸相关。
BackgroundTo evaluate the associations between maternal serum concentrations of high-density lipoprotein cholesterol (HDL-c) throughout pregnancy and neonatal birth weight (BW) and small for gestational age (SGA) births.MethodsA prospective cohort of 2241 pregnant women was followed from recruitment to delivery in three hospitals in Beijing, China between January 2014 and December 2017. Maternal fasting serum lipids concentrations were measured at gestational week 6–12, 16, 24 and 36. Major outcome was neonatal BW. The associations between maternal HDL-c and BW were estimated by linear regression and linear mixed-effects models. Odds ratios (ORs) and 95% confidence intervals of SGA births in relation to HDL-c were evaluated via logistic regression analysis.ResultsThere was a tendency that mothers with higher HDL-c concentrations throughout gestation gave birth to infants with lower BW. A negative association was found between maternal HDL-c concentrations and BW at 24th and 36th gestational weeks (B = − 34.044,P= 0.034; B = − 53.528,P= 0.000). The HDL-c trend of change was inversely associated with BW (B = − 442.736,P= 0.000). Mothers with SGA neonates had higher serum HDL-c concentration at the 36th gestational week (P< 0.01). The incidences of SGA in the three groups (HDL-c: 1.84–2.23 mmol/L, 2.24–2.59 mmol/L and ≥ 2.60 mmol/L) were higher than the group with the lowest concentration of HDL-c (< 1.83 mmol/L) (P< 0.01,P< 0.01,P< 0.001) at 36th week. Higher maternal HDL-c concentrations at 36th week (HDL-c: 1.84–2.23 mmol/L, 2.24–2.59 mmol/L and ≥ 2.60 mmol/L) were positively associated with the incidence of SGA (OR = 1.900,P= 0.008; OR = 1.893,P= 0.008; OR = 1.975,P= 0.004). The HDL-c trend of change was positively associated with SGA births (OR = 9.772,P= 0.000).ConclusionsMaternal serum HDL-c concentrations were inversely associated with BW at 24th and 36th gestational weeks. The high concentrations of HDL-c at the 36th gestational week increased the risk of SGA. The maternal HDL-c trend of change across pregnancy was associated with smaller neonatal size.