Increased primary cell-mediated immunity in culture subsequent to adriamycin or daunorubicin treatment of spleen donor mice.
Increased primary cell-mediated immunity in culture subsequent to adriamycin or daunorubicin treatment of spleen donor mice.
复制标题
对脾脏供体小鼠进行阿霉素或柔红霉素治疗后，培养物中原代细胞介导的免疫力增加。
作者：
F. Orsini;Z. Pavelic;E. Mihich
研究发现，与未经处理或环磷酰胺处理的动物的脾细胞相比，用阿霉素或柔红霉素处理的小鼠的脾细胞群在与同种异体肿瘤细胞培养期间产生更强的补体独立细胞毒性免疫反应。证明了这种效应的时间依赖性和药物剂量依赖性。药物治疗后供体小鼠中脾细胞群发生的变化在脾细胞的尼龙纤维粘附部分中是明显的。结果与药物治疗后脾脏中特定祖细胞或辅助细胞浓度增加的可能性一致。
Spleen cell populations from mice treated with Adriamycin or daunorubicin were found to develop a greater complement-independent cellular cytotoxic immune response during culture with allogeneic tumor cells than spleen cells from untreated or cyclophosphamide-treated animals. A temporal and drug dose dependence of this effect was demonstrated. The changes in spleen cell population occurring in the donor mice consequent to drug treatment were evident in the nylon woll-adherent fraction of the spleen cells. The results are consistent with the possibility that the concentration of specific progenitor or accessory cells in the spleen is increased consequent to drug treatment.