CARBAMAZEPINE DOES NOT AFFECT SHORT-LATENCY SOMATOSENSORY EVOKED-POTENTIALS - A LONGITUDINAL-STUDY IN NEWLY DIAGNOSED EPILEPSY
CARBAMAZEPINE DOES NOT AFFECT SHORT-LATENCY SOMATOSENSORY EVOKED-POTENTIALS - A LONGITUDINAL-STUDY IN NEWLY DIAGNOSED EPILEPSY
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DOI：
10.1111/j.1528-1157.1988.tb04410.x
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发表时间：
1988-03-01
期刊：
影响因子：
5.6
通讯作者：
MAMOLI, A
中科院分区：
文献类型：
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作者：
CARENINI, L;BOTTACCHI, E;MAMOLI, A
对12例新诊断的癫痫患者在服用卡马西平治疗1年前后进行正中神经刺激体感诱发电位的记录。药物的血浆浓度始终在治疗范围内。我们评估了颈椎水平（N9和N13）和顶骨头皮水平（P14，N20，P25）以及峰间水平（N9-N13，N13-N20，P14-N20）的早期成分的潜伏期。所有患者的任何参数均未出现异常，患者和对照组平均值之间或治疗1年前后患者平均值之间均无显著差异。
Somatosensory evoked potentials from median nerve stimulation were recorded in 12 patients with newly diagnosed epilepsy, before and after 1 year of treatment with carbamazepine. The plasma concentrations of the drug were consistently within therapeutic range. We assessed the latencies of the early components at the level of the cervical spine (N9 and N13) and on the parietal scalp (P14, N20, P25) and the interpeak latencies (N9-N13, N13-N20, P14-N20). None of the patients presented anomalies in any of the parameters, and there was no significant difference between the patient and control means or between the patient means before and after 1 year of treatment.