Role of cryptic genes in microbial evolution.
Role of cryptic genes in microbial evolution.
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神秘基因在微生物进化中的作用。
DOI：
10.1093/oxfordjournals.molbev.a040300
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发表时间：
1983
影响因子：
10.7
通讯作者：
Calhoun,DH
中科院分区：
文献类型：
--
作者：
Hall,BG;Yokoyama,S;Calhoun,DH
隐性基因是表型沉默的 DNA 序列，在个体的生命周期中通常不表达。然而，它们可能通过突变、重组、插入元件或其他遗传机制在大群体中的少数个体中被激活。对有关生化进化、生理学和分类学的微生物文献的考虑为微生物通过神秘基因的突变激活进行适应和进化的假设提供了基础。提出的证据并推导了一个数学模型，表明存在强大且具有生物学意义的机制来防止隐秘基因的丢失。我们认为，神秘基因作为遗传库的重要元素持续存在，为后代的突变激活做好了回忆的准备。隐性基因提供了一个多功能的内源遗传库，通过独立于遗传交换的机制增强物种的适应潜力。
Cryptic genes are phenotypically silent DNA sequences, not normally expressed during the life cycle of an individual. They may, however, be activated in a few individuals of a large population by mutation, recombination, insertion elements, or other genetic mechanisms. A consideration of the microbial literature concerning biochemical evolution, physiology, and taxonomy provides the basis for a hypothesis of microbial adaptation and evolution by mutational activation of cryptic genes. Evidence is presented, and a mathematical model is derived, indicating that powerful and biologically important mechanisms exist to prevent the loss of cryptic genes. We propose that cryptic genes persist as a vital element of the genetic repertoire, ready for recall by mutational activation in future generations. Cryptic genes provide a versatile endogenous genetic reservoir that enhances the adaptive potential of a species by a mechanism that is independent of genetic exchange.