Attributable risk of common and rare determinants of subarachnoid hemorrhage
Attributable risk of common and rare determinants of subarachnoid hemorrhage
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DOI：
10.1161/01.str.32.5.1173
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发表时间：
2001-05-01
期刊：
影响因子：
8.3
通讯作者：
Rinkel, GJE
中科院分区：
文献类型：
--
作者：
Ruigrok, YM;Buskens, E;Rinkel, GJE
背景和目的：吸烟、高血压、饮酒、常染色体显性遗传性多囊肾病（ADPKD）和蛛网膜下腔出血（SAH）阳性家族史是SAH的已知危险因素，为了有效预防，了解这些危险因素对SAH在普通人群中总体发生率的影响是关键的。因此，我们调查了SAH. Methods的危险因素的人群归因风险，我们从文献中检索了确定的SAH危险因素的相对风险和患病率，并计算了这些危险因素的人群归因风险。饮酒≥ 300 g/wk者占21%，吸烟者占20%。另外17%的病例可归因于高血压，11%的SAH阳性家族史，和0.3% ADPKD. Conclusions筛选和预防性治疗的SAH家族优势的患者单独将导致在一般人群中SAH的发病率适度降低。通过降低可改变的风险因素（饮酒、吸烟和高血压）的患病率，可以进一步降低患病率。
Background and Purpose-Smoking, hypertension, alcohol consumption, autosomal dominant polycystic kidney disease (ADPKD), and positive family history for subarachnoid hemorrhage (SAH) are well-known risk factors for SAH, For effective prevention, knowledge about the contribution of these risk factors to the overall occurrence of SAH in the general population is pivotal. We therefore investigated the population attributable risks of the risk factors for SAH.Methods-We retrieved the relative risk and prevalence of established risk factors for SAH from the literature and calculated the population attributable risks of these risk factors.Results-Drinking alcohol 100 to 299 g/wk accounted for 11% of the cases of SAH, drinking alcohol greater than or equal to 300 g/wk accounted for 21%, and smoking accounted for 20%. An additional 17% of the cases could be attributed to hypertension, 11% to a positive family history for SAH, and 0.3% to ADPKD.Conclusions-Screening and preventive treatment of patients with familial preponderance of SAH alone will cause a modest reduction of the incidence of SAH in the general population. Further reduction can be achieved by reducing the prevalence of the modifiable risk factors alcohol consumption, smoking, and hypertension.