An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder.
An open trial of pemoline in drug-dependent delinquents with attention-deficit hyperactivity disorder.
复制标题
一项对患有注意力缺陷多动障碍的药物依赖罪犯使用匹莫林的公开试验。
DOI：
10.1097/00004583-199608000-00012
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Crowley,TJ
中科院分区：
文献类型：
--
作者：
Riggs,PD;Thompson,LL;Mikulich,SK;Whitmore,EA;Crowley,TJ
行为障碍和物质使用障碍的青少年合并注意力缺陷多动障碍（ADHD）的比例很高; ADHD可能导致物质使用障碍和反社会行为的严重性和持续性。ADHD的治疗可以帮助患者利用物质和其他行为集中治疗。然而，鲜为人知的是ADHD症状的反应，以精神药理学干预物质依赖industrialistrions.METHODPilot数据为13名男性青少年与行为障碍，物质使用障碍，ADHD，在住宅物质使用治疗计划。患者接受匹莫林治疗。在基线时和匹莫林治疗约1个月后，获得Conners多动指数和连续性能任务的评分。还在基线和1个月时评估了身体活动测量。在最大剂量（1.2 - 3.3 mg/kg）治疗至少1周后进行给药后评估。匹莫林治疗后，平均Conners多动指数评分下降13.9%（p<0.002），平均运动性下降7%（p <0.04）。连续性能任务scores doesn 't change. CONCLUSION初步数据表明，pemoline可能是一个有用的治疗ADHD的物质依赖型罪犯，作者提出了一个对照试验pemoline在这样的青年。
OBJECTIVEAdolescents with conduct disorder and substance use disorders have high rates of comorbid attention-deficit hyperactivity disorder (ADHD); ADHD may contribute to the severity and persistence of substance use disorders and antisocial behaviors. Treatment of ADHD may help patients utilize substance and other behaviorally focused treatment. Yet little is known about the response of ADHD symptoms to psychopharmacological intervention in substance-dependent delinquents.METHODPilot data are presented for 13 male adolescents with conduct disorder, substance use disorders, and ADHD, in a residential substance use treatment program. Patients were treated with pemoline. Scores from the Conners Hyperactivity Index and continuous performance tasks were obtained at baseline and after about 1 month of treatment with pemoline. Physical activity measurements were also assessed at baseline and 1 month. Postmedication assessments were obtained after at least 1 week at maximal dosage (1.2 to 3.3 mg/kg).RESULTSMean Conners Hyperactivity Index scores declined 13.9% (p< .002) and mean motility declined 7% (p < .04) with pemoline treatment. Continuous performance task scores did not change.CONCLUSIONSPreliminary data indicate that pemoline may be a useful treatment for ADHD in substance-dependent delinquents; the authors propose a controlled trial of pemoline in such youths.