REFLEX AND INTENDED RESPONSES IN MOTOR CORTEX PYRAMIDAL TRACT NEURONS OF MONKEY
REFLEX AND INTENDED RESPONSES IN MOTOR CORTEX PYRAMIDAL TRACT NEURONS OF MONKEY
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DOI：
10.1152/jn.1976.39.5.1069
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
TANJI, J
中科院分区：
文献类型：
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作者：
EVARTS, EV;TANJI, J
猴子被训练成对手臂的扰动做出反应，按照扰动之前传递的指令。有两种可能的指令(推或拉)，猴子学会了做出相应的反应，而不考虑触发扰动的方向(推或拉)。对侧运动皮质臂区锥体束神经元(PTN)对触发扰动的反应有2个可分离成分：取决于扰动方向的较短潜伏期(20~25ms)反射成分和取决于先前指令的较长潜伏期(40~50ms)预期成分。预期的PTN放电可发生在臂区，潜伏期为50ms，即使在手臂扰动后，其对PTN的初始反射效应是抑制的。由适当身体部位的扰动触发的预期PTN反应发生的潜伏期比由听觉或视觉刺激触发的预期PTN反应的潜伏期更短。这些短潜伏期的PTN反应可能在短潜伏期但随意控制的肢体运动中发挥作用，以响应肢体扰动。
Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were 2 possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. Pyramidal tract neurons (PTN) in contralateral motor cortex arm area responded to the triggering perturbation with 2 dissociable components: a relatively short latency (20-25 ms) reflex component which depended on the direction of the perturbation and a longer latency (40-50 ms) intended component which depended on the prior instruction. Intended PTN discharge could occur in arm area with latencies of 50 ms, even after arm perturbations whose initial reflex effects on the PTN were inhibitory. Intended PTN responses triggered by perturbations of the appropriate body part occurred at shorter latencies than intended PTN responses triggered by auditory or visual stimuli. These short-latency intended PTN responses may play a role in the short-latency but volitionally controlled limb movements occurring in response to limb perturbations.