CHANGES IN PITUITARY OXYTOCIN AND VASOPRESSIN DURING THE ESTROUS-CYCLE AND AFTER OVARIAN HORMONES - EVIDENCE FOR MEDIATION BY NOREPINEPHRINE
CHANGES IN PITUITARY OXYTOCIN AND VASOPRESSIN DURING THE ESTROUS-CYCLE AND AFTER OVARIAN HORMONES - EVIDENCE FOR MEDIATION BY NOREPINEPHRINE
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DOI：
10.1016/0024-3205(78)90373-9
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发表时间：
1978-01-01
期刊：
影响因子：
6.1
通讯作者：
JACOBOWITZ, DM
中科院分区：
文献类型：
--
作者：
CROWLEY, WR;ODONOHUE, TL;JACOBOWITZ, DM
在周期雌性大鼠中，垂体催产素和加压素水平在动情前期早上达到最高，在动情期间下降，在动情后期达到最低。与动情后期间情期相比，动情前期和动情期室旁核中去甲肾上腺素水平降低。去甲肾上腺素在视上核中无变化。给去卵巢大鼠苯甲酸雌二醇54小时后，垂体中催产素升高。这种升高不受随后注射雌激素或孕激素的影响。雌激素预处理不影响垂体中的加压素水平，但48 h后第2次注射雌激素或孕酮可增加垂体中的加压素水平（在第2次注射后6 h测量）。第二次注射雌激素后30 h，加压素下降。升高垂体后叶加压素的卵巢激素治疗降低室旁核中去甲肾上腺素的稳态水平，并在施用儿茶酚胺合成抑制剂α-肾上腺素后减少去甲肾上腺素的消耗。甲基酪氨酸，表明营业额下降。卵巢激素不影响视上核的去甲肾上腺素。垂体后叶激素在生殖过程中的作用和室旁核中去甲肾上腺素能机制的作用，在介导卵巢类固醇对垂体加压素的影响，建议。
Pituitary levels of oxytocin and vasopressin were maximal on the morning of proestrus, declined during estrus and were lowest on metestrus in cycling female rats. Norepinephrine levels in the paraventricular nucleus were decreased on proestrus and estrus when compared with metestrus-diestrus. Norepinephrine did not vary in the supraoptic nucleus. Administration of estradiol benzoate to ovariectomized rats elevated oxytocin in the pituitary 54 h later. This elevation was not affected by a subsequent injection of estrogen or progesterone. Estrogen priming did not affect vasopressin levels in the pituitary, but a 2nd injection of estrogen or of progesterone 48 h later increased vasopressin in the piuitary when measured 6 h after the 2nd injection. Vasopressin was decreased 30 h after a 2nd injection of estrogen. The ovarian hormone treatments that elevated pituitary vasopressin decreased steady state levels of norepinephrine in the paraventricular nucleus and reduced the depletion of norepinephrine after administration of the catecholamine synthesis inhibitor .alpha.-methyltyrosine, suggesting a decrease in turnover. Ovarian hormones did not affect norepinephrine in the supraoptic nucleus. A role for posterior pituitary hormones in reproductive processes and a role for noradrenergic mechanisms in the paraventricular nucleus, in mediating the effects of ovarian steroids on pituitary vasopressin, are suggested.