Prechemotherapy alterations in brain function in women with breast cancer
Prechemotherapy alterations in brain function in women with breast cancer
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DOI：
10.1080/13803390903032537
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Welsh, Robert C.
中科院分区：
文献类型：
--
作者：
Cimprich, Bernadine;Reuter-Lorenz, Patricia;Welsh, Robert C.
尽管有临床报道与癌症化疗相关的认知缺陷，但其潜在的大脑机制尚不清楚。本研究采用功能性磁共振成像（fMRI）检查了局部乳腺癌化疗前女性的选择性注意力和工作记忆。在fMRI期间对患者进行了既定的选择性注意力和工作记忆任务测试。与健康对照组相比，患者表现出（a）在高要求任务条件下双侧大脑激活，并招募了注意力/工作记忆回路的其他成分，（B）准确性较低，任务执行较慢。结果表明，在任何化疗之前，认知功能都会受损，并提出了进一步研究的关键问题。
Despite clinical reports of cognitive deficits associated with cancer chemotherapy, the underlying brain mechanisms are not clear. This research examined selective attention and working memory using functional magnetic resonance imaging (fMRI) in women before chemotherapy for localized breast cancer. Patients were tested with an established selective attention and working memory task during fMRI. Compared with healthy controls, patients showed (a) bilateral brain activation in high-demand task conditions with recruitment of additional components of attention/working memory circuitry, and (b) less accurate and slower task performance. Results indicate compromised cognitive functioning before any chemotherapy and raise key questions for further research.