Early life experience alters response of adult neurogenesis to stress
Early life experience alters response of adult neurogenesis to stress
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DOI：
10.1038/nn1290
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发表时间：
2004-08-01
影响因子：
25
通讯作者：
Gould, E
中科院分区：
文献类型：
--
作者：
Mirescu, C;Peters, JD;Gould, E
母亲的剥夺会导致海马体相关的行为和神经内分泌功能的持续异常，海马体是一个大脑区域，在整个生命过程中，随着经历的变化，它会显示出相当大的结构变化。在这里，我们表明，不良的经验，在生命的早期影响成年海马神经发生的调节。更具体地说，在幼年时与母体分离的成年大鼠的齿状回中观察到细胞增殖和未成熟神经元产生的减少。虽然母体分离的大鼠表现出正常的皮质酮基础水平，在这些大鼠中的细胞增殖的抑制可以通过降低皮质酮低于对照值来逆转。此外，正常的应激诱导的细胞增殖和神经发生的抑制，尽管正常激活的下丘脑垂体肾上腺（HPA）轴，没有观察到在母体分离的大鼠。我们的研究结果表明，早期的不良经历抑制结构可塑性通过对糖皮质激素的超敏反应，并减少海马体的能力，以应对成年期的压力。
Maternal deprivation produces persistent abnormalities in behavioral and neuroendocrine functions associated with the hippocampus, a brain region that shows considerable structural change in response to experience throughout life. Here we show that adverse experience early in life affects the regulation of adult neurogenesis in the hippocampus. More specifically, a decrease in cell proliferation and immature neuron production are observed in the dentate gyrus of adult rats that are maternally separated as pups. Although maternally separated rats show normal basal levels of corticosterone, the suppression of cell proliferation in these rats can be reversed by lowering corticosterone below the control value. In addition, normal stress-induced suppression of cell proliferation and neurogenesis, despite normal activation of the hypothalamic pituitary adrenal (HPA) axis, is not observed in maternally separated rats. Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood.