The Predictive Value of Thromboelastogram in the Evaluation of Patients with Suspected Acute Venous Thromboembolism
The Predictive Value of Thromboelastogram in the Evaluation of Patients with Suspected Acute Venous Thromboembolism
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DOI：
10.1159/000502348
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发表时间：
2020-06-01
影响因子：
2.4
通讯作者：
Ganzel, Chezi
中科院分区：
文献类型：
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作者：
Abu Assab, Tareq;Raveh-Brawer, David;Ganzel, Chezi
简介：这项前瞻性研究的目的是检查血栓弹力图（TEG）是否可以预测静脉血栓栓塞（VTE）的存在，在到达急诊室的患者的体征/症状，提高了急性VTE的怀疑。方法：每个患者进行了D-二聚体和所有TEG参数，包括：反应时间、血凝块形成时间、α角、最大振幅、血凝块粘弹性、凝血指数和30分钟时的血凝块溶解。对于分类变量，使用卡方检验或Fisher精确检验，结果：2016年共入组109例患者，中位年龄55.7（21-89）岁。18例患者被诊断为VTE。分析不同的TEG参数，作为连续变量和分类变量，没有发现VTE阳性和VTE阴性患者之间的统计学显著差异。结合不同的TEG参数或划分队列根据性别，临床怀疑静脉血栓栓塞（井的标准），或不同水平的D-二聚体没有改变的analysis.Conclusion结果：目前的研究不能证明任何TEG参数的显着价值作为预测静脉血栓栓塞的患者来到急诊室的体征/症状，提高怀疑静脉血栓栓塞。
Introduction:The objective of this prospective study was to examine whether thromboelastogram (TEG) can predict the presence of venous thromboembolism (VTE) in patients who arrive at the emergency room with signs/symptoms that raise the suspicion of acute VTE.Methods:Every patient was tested for D-dimer and all TEG parameters, including: reaction time, clot time formation, alpha-angle, maximal amplitude, clot viscoelasticity, coagulation index, and clot lysis at 30 min. For categorical variables, chi(2) or the Fisher exact test were used, and for continuous variables thettest or other non-parametric tests were used.Results:During 2016, a total of 109 patients were enrolled with a median age of 55.7 (21-89) years. Eighteen patients were diagnosed with VTE. Analyzing the different TEG parameters, both as continuous and categorical variables, did not reveal a statistically significant difference between VTE-positive and VTE-negative patients. Combining different TEG parameters or dividing the cohort according to gender, clinical suspicion of VTE (Well's criteria), or different levels of D-dimer did not change the results of the analysis.Conclusion:The current study could not demonstrate a significant value of any TEG parameter as a predictor of VTE among patients who came to the emergency room with signs/symptoms that raise the suspicion of VTE.