The YOUth cohort study: MRI protocol and test-retest reliability in adults
The YOUth cohort study: MRI protocol and test-retest reliability in adults
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DOI：
10.1016/j.dcn.2020.100816
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发表时间：
2020-10-01
影响因子：
4.7
通讯作者：
Mandl, Rene C. W.
中科院分区：
文献类型：
--
作者：
Buimer, Elizabeth E. L.;Pas, Pascal;Mandl, Rene C. W.
青年队列研究是对普通人群大脑发育的一项独特的纵向研究。作为青年研究的一部分，2000名儿童将在8岁、9岁或10岁时被纳入研究，并计划在青春期每三年返回一次。收集磁共振成像（MRI）脑部扫描，包括结构t1加权成像、弥散加权成像（DWI）、静息状态功能MRI和任务型功能MRI。在这里，我们提供了一个全面的报告，在青少年，儿童和青少年的磁共振采集，包括从每种类型的扫描得出的大脑测量的测试-重测信度。为了测量重新测试的可靠性，17名成年人使用完整的YOUth MRI协议进行了两次扫描，每次扫描间隔一周。计算类内相关系数以量化信度。从结构t1加权和DWI扫描得到的全脑测量是可靠的。静息状态功能连通性是中等可靠的，抑制任务（停与走）和情绪任务（脸与房子）的大脑功能测量也是如此。我们的研究结果补充了以前的研究，提出了不同MRI模式收集的区域脑测量结果的可靠性。青年促进数据共享，旨在获得可靠和高质量的数据。在这里，我们表明，使用国家的最先进的青年核磁共振协议脑测量可以可靠地估计。
The YOUth cohort study is a unique longitudinal study on brain development in the general population. As part of the YOUth study, 2000 children will be included at 8, 9 or 10 years of age and planned to return every three years during adolescence. Magnetic resonance imaging (MRI) brain scans are collected, including structural T1-weighted imaging, diffusion-weighted imaging (DWI), resting-state functional MRI and task-based functional MRI. Here, we provide a comprehensive report of the MR acquisition in YOUth Child & Adolescent including the test-retest reliability of brain measures derived from each type of scan. To measure test-retest reliability, 17 adults were scanned twice with a week between sessions using the full YOUth MRI protocol. Intraclass correlation coefficients were calculated to quantify reliability. Global brain measures derived from structural T1-weighted and DWI scans were reliable. Resting-state functional connectivity was moderately reliable, as well as functional brain measures for both the inhibition task (stop versus go) and the emotion task (face versus house). Our results complement previous studies by presenting reliability results of regional brain measures collected with different MRI modalities. YOUth facilitates data sharing and aims for reliable and high-quality data. Here we show that using the state-of-the art YOUth MRI protocol brain measures can be estimated reliably.