Testosterone replacement in men
Testosterone replacement in men
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DOI：
10.1097/med.0b013e328305081a
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发表时间：
2008-08-01
影响因子：
3.2
通讯作者：
Cunningham, Glenn R.
中科院分区：
文献类型：
--
作者：
Beg, Sumbul;Al-Khoury, Lara;Cunningham, Glenn R.
综述的目的是总结有关男性性腺功能减退症的患病率、流行病学、诊断和治疗方面的最新研究结果。基于人口的最新研究表明，低睾酮水平预示着2型糖尿病、代谢综合征和生存的发展。尽管需要一项大型临床试验来评估长期受益/风险比，但睾酮替代疗法已被证明对性功能、情绪、身体成分、肌肉质量和骨密度有积极影响。由于其潜在的副作用，对安全性的仔细监测是至关重要的，主要是在老年男性。摘要睾酮替代疗法是治疗性腺功能减退症男性的主要疗法，50岁以上的男性应密切监测治疗情况。
Purpose of reviewTo summarize recent findings related to the prevalence, epidemiology, diagnosis, and treatment of male hypogonadism.Recent findingsPopulation-based studies indicate that low testosterone levels predict development of type 2 diabetes mellitus, metabolic syndrome, and survival. Although a large clinical trial is needed to assess the long-term benefit-to-risk ratio, testosterone replacement therapy has been shown to have positive effects on sexual function, mood, body composition, muscle mass, and bone density. Due to its potential side effects, careful monitoring for safety is critical, mainly in old men.SummaryTestosterone replacement therapy is the mainstay of treatment for men with hypogonadism, treatment should be closely monitored in men over age 50.