SEQUENCE-ANALYSIS AND NEURONAL EXPRESSION OF FASCICLIN-I IN GRASSHOPPER AND DROSOPHILA
SEQUENCE-ANALYSIS AND NEURONAL EXPRESSION OF FASCICLIN-I IN GRASSHOPPER AND DROSOPHILA
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DOI：
10.1016/0092-8674(88)90574-0
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发表时间：
1988-05-20
期刊：
影响因子：
64.5
通讯作者：
GOODMAN, CS
中科院分区：
文献类型：
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作者：
ZINN, K;MCALLISTER, L;GOODMAN, CS
成束蛋白I、II和III糖蛋白在昆虫胚胎中的轴突束（束）的不同子集上表达，并且因此是参与生长锥引导的表面识别分子的候选者。在这里，我们提出了蝗虫fasciclin I的序列和果蝇fasciclin I同源物的鉴定和序列。在这两个物种中，成束蛋白I似乎是一种具有信号序列但没有跨膜区的外源性膜蛋白;该蛋白质包含四个同源结构域，每个结构域约150个氨基酸。针对果蝇fasciclin I的抗体揭示，它在胚胎中枢神经系统中的连合轴突通路的子集的表面上和外周神经系统中的所有感觉轴突通路上表达。这种表达模式与蚱蜢相似。
The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Drosophila fasciclin I homolog. In both species, fasciclin I appears to be an extrinsic membrane protein with a signal sequence but no transmembrane region; the protein comprises four homologous domains of approximately 150 amino acids each. Antibodies against Drosophila fasciclin I reveal that it is expressed on the surface of a subset of commissural axon pathways in the embryonic central nervous system and on all sensory axon pathways in the peripheral nervous system. This pattern of expression is similar to that in grasshopper.